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Ribonucleoprotein, U2 Small Nuclear

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Definition: A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U2 snRNP along with other small nuclear ribonucleoproteins (U1, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U2 snRNA forms base pairs with conserved sequence motifs at the branch point, which associates with a heat- and RNAase-sensitive factor in an early step of splicing.      Other names U2 snRNP; U2 Small Nuclear Ribonucleoproteins; Small Nuclear Ribonucleoproteins, U2; Ribonucleoproteins, Small, U2
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
RAD201 protein, Drosophila  0   *Ribonucleoprotein, U2 Small Nuclear *Drosophila Proteins. PLoS Genet 2006 Dec 8;2(12):e178
SPF45 protein, Drosophila  0   *Ribonucleoprotein, U2 Small Nuclear *Drosophila Proteins DNA Repair. PLoS Genet 2006 Dec 8;2(12):e178
YSF3 protein, S cerevisiae  0   *Ribonucleoprotein, U2 Small Nuclear *Saccharomyces cerevisiae Proteins. Mol Cell Biol 2005 Dec;25(24):10745-54
prp10 protein, S pombe  0   *Phosphoproteins *Ribonucleoprotein, U2 Small Nuclear *Schizosaccharomyces pombe Proteins Spliceosomes.
Sf3b1 protein, mouse  0   *Phosphoproteins *Ribonucleoprotein, U2 Small Nuclear Spliceosomes.
MSL1 protein, S cerevisiae  0   *Ribonucleoprotein, U2 Small Nuclear *Saccharomyces cerevisiae Proteins.
U2A' protein, human  0   *Ribonucleoprotein, U2 Small Nuclear.
RDS3 protein, S cerevisiae  0   *Ribonucleoprotein, U2 Small Nuclear *Saccharomyces cerevisiae Proteins. Mol Cell Biol. 2003 Oct;23(20):7339-49
DDX46 protein, human  EC 3.6.1.-   *Ribonucleoprotein, U2 Small Nuclear *DEAD-box RNA Helicases. EMBO J 2002 Sep 16;21(18):4978-88
U2 small nuclear ribonucleoprotein p14  0   Ribonucleoprotein, U2 Small Nuclear. EMBO J 2001 Aug 15;20(16):4536-46
IST3 protein, S cerevisiae  0   *Ribonucleoprotein, U2 Small Nuclear *Saccharomyces cerevisiae Proteins RNA Splicing. Mol Cell Biol 2001 May;21(9):3037-46
DDX42 protein, human  EC 3.6.1-   *Ribonucleoprotein, U2 Small Nuclear *DEAD-box RNA Helicases. Biochim Biophys Acta 2000 Apr 15;1501(1):63-9
HSH155 protein, S cerevisiae  0   *Ribonucleoprotein, U2 Small Nuclear *Saccharomyces cerevisiae Proteins. Mol Cell Biol 2000 Mar;20(6):2176-85
RSE1 protein, S cerevisiae  0   *Ribonucleoprotein, U2 Small Nuclear *Saccharomyces cerevisiae Proteins RNA Splicing. EMBO J 1999 Jun 15;18(12):3463-74
YIB9 protein, S cerevisiae  0   *Ribonucleoprotein, U2 Small Nuclear *Saccharomyces cerevisiae Proteins Saccharomyces. EMBO J 1998 Nov 2;17(21):6348-58
LEA1 protein, S cerevisiae  0   *Ribonucleoprotein, U2 Small Nuclear *Saccharomyces cerevisiae Proteins. EMBO J 1998 Nov 2;17(21):6348-58
SF3B1 protein, human  0   *Phosphoproteins *Ribonucleoprotein, U2 Small Nuclear Spliceosomes. Genes Dev 1998 May 15;12(10):1409-14
HSH49 protein, S cerevisiae  0   *Ribonucleoprotein, U2 Small Nuclear *Saccharomyces cerevisiae Proteins. RNA 1998 Jan;4(1):1-10
U2A protein, Drosophila  0   *Ribonucleoprotein, U2 Small Nuclear *Drosophila Proteins. EMBO J 1995 Sep 15;14(18):4540-50
SF3A1 protein, human  0   *Ribonucleoprotein, U2 Small Nuclear. Proc Natl Acad Sci U S A 1994 Jul 5;91(14):6403-7
splicing factor 3a  0   *Ribonucleoprotein, U2 Small Nuclear Zinc Fingers. Proc Natl Acad Sci U S A 1994 Jul 5;91(14):6403-7
U2 snRNP, Trypanosoma brucei  0   *Protozoan Proteins *Ribonucleoprotein, U2 Small Nuclear. EMBO J 1993 Mar;12(3):1239-48

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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