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DEAD-box RNA Helicases

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Definition: A large family of RNA helicases that share a common protein motif with the single letter amino acid sequence D-E-A-D (Asp-Glu-Ala-Asp). In addition to RNA helicase activity, members of the DEAD-box family participate in other aspects of RNA metabolism and regulation of RNA function.     
Examples DEAD Box Protein 20 		Other names RNA Helicases, DEAD-box; RNA Helicase, p68; Helicases, DEAD-box RNA; Helicase, p68 RNA; DEAD box RNA Helicases; p68 RNA Helicase; p68 DEAD Box Protein; DEAD Box Helicase p68
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
DHX33 protein, human  EC 3.6.1.-   *DEAD-box RNA Helicases. Mol Cell Biol. 2011 Dec;31(23):4676-91.
eIF4a3 protein, rat  EC 3.6.1.-   *DEAD-box RNA Helicases. Nucleic Acids Res. 2011 Sep 1;39(17):7730-9
DDX60 protein, mouse  EC 3.6.1.-   *DEAD-box RNA Helicases. Mol Cell Biol 2011 Sep;31(18):3802-19
DDX60 protein, human  EC 3.6.1.-   *DEAD-box RNA Helicases. Mol Cell Biol 2011 Sep;31(18):3802-19
Ddx18 protein, zebrafish  EC 3.6.1.-   *Zebrafish Proteins *DEAD-box RNA Helicases. Blood 2011 Jul 28;118(4):903-15
RH39 protein, Arabidopsis  EC 3.6.1.-   *Arabidopsis Proteins *DEAD-box RNA Helicases. Plant J 2010 Sep;63(5):766-77
Ise1 protein, Arabidopsis  EC 3.6.1.-   *Arabidopsis Proteins *DEAD-box RNA Helicases. Curr Biol 2010 Jun 8;20(11):989-93
Ddx51 protein, mouse  EC 3.6.1.-   *DEAD-box RNA Helicases. Mol Cell Biol 2010 Jun;30(12):2947-56
RH8 protein, Arabidopsis  EC 2.7.7.-   *Arabidopsis Proteins *DEAD-box RNA Helicases. Plant Physiol 2010 Jan;152(1):255-66
SrmB protein, E coli  EC 3.6.1.-   *Escherichia coli Proteins *DEAD-box RNA Helicases. Nucleic Acids Res 2009 Oct;37(19):6540-9
Prp22 protein, human  EC 2.7.7.-   *DEAD-box RNA Helicases. Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 Sep 1;65(Pt 9):956-8
Supv3L1 protein, mouse  EC 2.7.7.-   *DEAD-box RNA Helicases. Mamm Genome. 2009 Feb;20(2):92-108
DDX1 protein, mouse  EC 2.7.7.-   *DEAD-box RNA Helicases. Oncogene 2009 May 28;28(21):2142-51
Dbp5 protein, S pombe  EC 2.7.7.-   *Schizosaccharomyces pombe Proteins *DEAD-box RNA Helicases. J Mol Biol 2009 Apr 24;388(1):1-10
gemin3 protein, Drosophila  EC 2.7.7.-   *Drosophila Proteins *DEAD-box RNA Helicases. PLoS Genet 2008 Nov;4(11):e1000265
DDX-23 protein, C elegans  EC 2.7.7.-   *Caenorhabditis elegans Proteins *DEAD-box RNA Helicases. Dev Dyn 2008 Sep;237(9):2367-77
Me31B protein, Drosophila  EC 2.7.7.-   *Drosophila Proteins *DEAD-box RNA Helicases. Proc Natl Acad Sci U S A 1991 Mar 15;88(6):2113-7
DDX18 protein, human  EC 3.6.1.-   *DEAD-box RNA Helicases. Oncol Res 2007;16(12):549-56
DDX21 protein, mouse  EC 2.7.7.-   *DEAD-box RNA Helicases. J Biol Chem 2008 Mar 14;283(11):7046-53
RhlE protein, E coli  EC 2.7.7.-   *Escherichia coli Proteins *DEAD-box RNA Helicases. RNA 2008 Feb;14(2):381-9
centroid protein, Xenopus  EC 2.7.7.-   *Xenopus Proteins *DEAD-box RNA Helicases. Int J Dev Biol 2007;51(8):701-6
STRS2 protein, Arabidopsis  EC 2.7.7.-   *Arabidopsis Proteins *DEAD-box RNA Helicases. Plant Physiol 2007 Nov;145(3):814-30
STRS1 protein, Arabidopsis  EC 2.7.7.-   *Arabidopsis Proteins *DEAD-box RNA Helicases. Plant Physiol 2007 Nov;145(3):814-30
VBH-1 protein, C elegans  EC 2.7.7.-   *Caenorhabditis elegans Proteins *DEAD-box RNA Helicases. Genesis 2007 Sep;45(9):533-46
GLH-1 protein, C elegans  EC 2.7.7.-   *Caenorhabditis elegans Proteins *DEAD-box RNA Helicases. Dev Biol 2002 Nov 15;251(2):333-47
Drh-3 protein, C elegans  EC 2.7.7.-   *Caenorhabditis elegans Proteins *DEAD-box RNA Helicases. Genes Cells 2007 Sep;12(9):997-1010
ChlR1 protein, mouse  EC 2.7.7.-   *DEAD-box RNA Helicases. Cell Cycle 2007 Jul;6(13):1646-54
Dhx32 protein, mouse  EC 2.7.1.37   *DEAD-box RNA Helicases. Exp Mol Pathol 2007 Aug;83(1):115-8
SART3 protein, zebrafish  EC 2.7.7.-   *Zebrafish Proteins *DEAD-box RNA Helicases. Mech Dev 1997 Aug;66(1-2):95-105
Ddx39b protein, mouse  EC 2.7.7.-   *DEAD-box RNA Helicases. DNA Seq 2006 Aug;17(4):292-9
Ifih1protein, mouse  EC 3.6.1.-   *DEAD-box RNA Helicases. Nature. 2006 May 4;441(7089):101-5
DDX25 protein, human  EC 3.6.1.-   *DEAD-box RNA Helicases. Hum Reprod. 2006 Mar;21(3):755-9
Dicer1 protein, mouse  EC 3.1.26.3   *Ribonuclease III *DEAD-box RNA Helicases. Cytogenet Genome Res. 2006;113(1-4):138-43
Ddx5 protein, rat  EC 2.7.1.37   *DEAD-box RNA Helicases.
Ddx5 protein, mouse  EC 3.6.1.-   *DEAD-box RNA Helicases.
Ddx5 protein, human  EC 3.6.1.-   *DEAD-box RNA Helicases.
Dhx9 protein, mouse  0   *DEAD-box RNA Helicases.
LOS4 protein, Arabidopsis  EC 3.6.1.-   *Arabidopsis Proteins *DEAD-box RNA Helicases. Plant Cell. 2005 Jan;17(1):256-67
Uap56 protein, S pombe  EC 3.6.1.-   *Schizosaccharomyces pombe Proteins *DEAD-box RNA Helicases. EMBO J 2005 Jul 20;24(14):2512-23
Ddx58 protein, mouse  EC 3.6.1.-   *DEAD-box RNA Helicases. Immunity 2005 Jul;23(1):19-28
RhlB protein, E coli  EC 3.6.1.-   *Escherichia coli Proteins *DEAD-box RNA Helicases. New Biol 1991 Sep;3(9):886-95
DDX21 protein, human  EC 3.6.1.-   *DEAD-box RNA Helicases.
DDX41 protein, human  EC 3.6.1.-   *DEAD-box RNA Helicases. Int J Oncol 2005 Mar;26(3):685-9
DDX10 protein, human  EC 3.6.1.-   *DEAD-box RNA Helicases. Cancer Genet Cytogenet 2005 Mar;157(2):104-8
DDX39A protein, human  EC 3.6.1.-   *DEAD-box RNA Helicases.
DDX23 protein, human  EC 2.7.7.-   *DEAD-box RNA Helicases.
vasa protein, zebrafish  EC 3.6.1.-   *Zebrafish Proteins *DEAD-box RNA Helicases.
DDX4 protein, human  EC 3.6.1.-   *DEAD-box RNA Helicases.
DBP5 protein, S cerevisiae  EC 3.6.1.-   *Nucleocytoplasmic Transport Proteins *Saccharomyces cerevisiae Proteins *DEAD-box RNA Helicases.
DED1 protein, S cerevisiae  EC 3.6.1.-   *Saccharomyces cerevisiae Proteins *DEAD-box RNA Helicases.
sum3 protein, S pombe  EC 2.7.7.-.   *Cell Cycle Proteins *Schizosaccharomyces pombe Proteins *DEAD-box RNA Helicases RNA Helicases.
DDX3Y protein, human  EC 3.6.1.-   *DEAD-box RNA Helicases.
MPH1 protein, S cerevisiae  EC 3.6.1.-   *Saccharomyces cerevisiae Proteins *DEAD-box RNA Helicases.
DBP6 protein, S cerevisiae  EC 2.7.7.-.   *Saccharomyces cerevisiae Proteins *DEAD-box RNA Helicases.
Ddx6 protein, mouse  EC 2.7.7.-.   *Proto-Oncogene Proteins *DEAD-box RNA Helicases.
DBP8 protein, S cerevisiae  EC 3.6.1.-   *Saccharomyces cerevisiae Proteins *DEAD-box RNA Helicases.
Ddx1 protein, Drosophila  EC 2.7.7.-   *Drosophila Proteins *DEAD-box RNA Helicases.
Ddx1 protein, rat  EC 3.6.1.-   *DEAD-box RNA Helicases.
ATSUV3 protein, Arabidopsis  0   *Arabidopsis Proteins *DEAD-box RNA Helicases.
Has1 protein, S cerevisiae  EC 3.1.6.-   *Saccharomyces cerevisiae Proteins *DEAD-box RNA Helicases. Mol Microbiol 2004 Apr;52(1):141-58
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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