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DNA Glycosylases

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Definition: A family of DNA repair enzymes that recognize damaged nucleotide bases and remove them by hydrolyzing the N-glycosidic bond that attaches them to the sugar backbone of the DNA molecule. The process called BASE EXCISION REPAIR can be completed by a DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE which excises the remaining RIBOSE sugar from the DNA.     
Examples DNA-Formamidopyrimidine Glycosylase; Thymine DNA Glycosylase; Uracil-DNA Glycosidase 		Other names Glycosylases, DNA; Glycosylase, Methylpurine DNA; Glycosylase, DNA; DNA N glycosidase; DNA Glycosylase, Methylpurine; Methylpurine DNA Glycosylase; DNA Glycosylase; DNA N-glycosidase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Amun protein, Drosophila  0   *Drosophila Proteins *DNA Glycosylases. Genetics 2009 Aug;182(4):1061-76
cyclin O, mouse  0   *Cyclins DNA Glycosylases. Cell Death Differ 2009 Feb;16(2):230-43
DML3 protein, Arabidopsis  EC 3.2.2.-   *Arabidopsis Proteins *DNA Glycosylases. Proc Natl Acad Sci U S A 2007 Apr 17;104(16):6752-7
DML2 protein, Arabidopsis  EC 3.2.2.-   *Arabidopsis Proteins *DNA Glycosylases. Proc Natl Acad Sci U S A 2007 Apr 17;104(16):6752-7
Ogg1 protein, Drosophila  EC 3.2.2.-   *Drosophila Proteins *DNA Glycosylases. Free Radic Biol Med 2006 Sep 1;41(5):757-64
Ogg1 protein, S cerevisiae  EC 3.2.2.-   *Saccharomyces cerevisiae Proteins *DNA Glycosylases DNA Repair. Proc Natl Acad Sci U S A 2005 Sep 20;102(38):13538-43
Neil2 protein, mouse  EC 3.2.2.-   *DNA Glycosylases. DNA Repair (Amst) 2005 Apr 4;4(4):419-31
OGG1 protein, Arabidopsis  EC 3.2.2.-   *Arabidopsis Proteins *DNA Glycosylases. Biochem Biophys Res Commun 2005 Apr 15;329(3):869-72
Mag1 protein, S pombe  EC 3.2.2.-   *Schizosaccharomyces pombe Proteins *DNA Glycosylases DNA Repair. Gene 1996 Oct 24;177(1-2):229-35
CCNO protein, human  EC 3.2.2.-   *DNA Glycosylases. Biochim Biophys Acta 1991 Feb 16;1088(2):197-207
Nth1 protein, S pombe  0   *Multienzyme Complexes *Schizosaccharomyces pombe Proteins *DNA-(Apurinic or Apyrimidinic Site) Lyase *DNA Glycosylases DNA Repair. Nucleic Acids Res 2004;32(17):5119-25
Ogg1 protein, mouse  EC 3.2.2.-   *DNA Glycosylases. FASEB J 2004 Mar;18(3):595-7
OGG1 protein, rat  EC 3.2.2.-   *DNA Glycosylases. Nucleic Acids Res 1998 Nov 15;26(22):5199-202
Neil1 protein, mouse  EC 3.2.2.-   *DNA Glycosylases. Nucleic Acids Res 2004;32(1) (dup#5);338-45
oxoguanine glycosylase 1, human  EC 3.2.2.-   *DNA Glycosylases. Biochemistry 2003 Sep 30;42(38):11373-81
NEIL2 protein, human  EC 4.2.99.18   *DNA-(Apurinic or Apyrimidinic Site) Lyase *DNA Glycosylases.
NEIL1 protein, human  EC 3.2.2.-   *DNA Glycosylases. Nucleic Acids Res 2002 Nov 15;30(22):4926-36
MAG1 protein, S cerevisiae  EC 3.2.2.21   *Saccharomyces cerevisiae Proteins *DNA Glycosylases. Yeast 1994 May;10(5):687-91
5-methylcytosine-DNA glycosylase  EC 3.2.2.-   *DNA Glycosylases. J Biol Chem 1995 Apr 28;270(17):9734-9
MutB protein, Salmonella typhimurium  EC 3.2.2.-   *Bacterial Proteins *DNA Glycosylases. J Bacteriol 1993 Jan;175(2):541-3
DNA-3-methyladenine glycosidase II  EC 3.2.2.21   *DNA Glycosylases DNA Repair. Proc Natl Acad Sci U S A 1981 Feb;78(2):856-60
mutY adenine glycosylase  EC 3.2.2.-   *DNA Glycosylases. Proc Natl Acad Sci USA 1989;86(22):8877
cytosine-DNA glycosidase  EC 3.2.2.-   *DNA Glycosylases. Biochemistry 1989;28(4):1488
pyrimidine-5'-nucleotide nucleosidase  EC 3.2.2.10   *DNA Glycosylases. Br J Haematol 1986;63(3):471
hydroxymethyluracil DNA glycosylase  EC 3.2.2.-   *DNA Glycosylases. Proc Natl Acad Sci USA 1984;81(13):4003
7-methylguanine DNA glycosylase  EC 3.2.2.-   *DNA Glycosylases. Basic Life Sci 1983;24:545
deoxyribopyrimidine endonucleosidase  EC 3.2.2.17   *DNA Glycosylases. J Biol Chem 1982;257(22):13465
5-bromouracil DNA glycosylase  EC 3.2.2.-   *DNA Glycosylases. Cell Biol Internat 1981;5(6):551
3-methyladenine-DNA glycosylase  EC 3.2.2.-   *DNA Glycosylases DNA Repair. Biochemistry 17(11):2110;1978; Biochemistry 18(5):911;1979; Nature 259(5538):64;1976

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