Definition: A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.
Other names Endonuclease, Apurinic DNA; Endonuclease, Apurinic; Endonuclease, Apurine-Apyrimidine; Endonuclease, AP; DNA Endonuclease, Apurinic; Apurine Apyrimidine Endonuclease; Apurinic Endonuclease; Apurine-Apyrimidine Endonuclease; AP Lyase; AP Endonuclease; Endodeoxyribonuclease (Apurinic or Apyrimidinic); DNA Lyase (Apurinic or Apyrimidinic); Apurinic DNA Endonuclease
