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Cyclins

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Definition: A large family of regulatory proteins that function as accessory subunits to a variety of CYCLIN-DEPENDENT KINASES. They generally function as ENZYME ACTIVATORS that drive the CELL CYCLE through transitions between phases. A subset of cyclins may also function as transcriptional regulators.  note specifics   
See Also Maturation-Promoting Factor
Examples Cyclin A; Cyclin B; Cyclin C; Cyclin D; Cyclin E; Cyclin G; Cyclin H; Cyclin I; Cyclin T
Other names Cyclin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CNNM2 protein, human  0   *Cyclins. Am J Hum Genet 2011 Mar 11;88(3):333-43
cables1 protein, zebrafish  0   *Carrier Proteins *Phosphoproteins *Cyclins *Zebrafish Proteins. Mol Reprod Dev. 2011 Jan;78(1):22-32
TDM1 protein, Arabidopsis  0   *Cyclins *Arabidopsis Proteins. Plant Cell 2010 Nov;22(11):3791-803
cyclin Y protein, Drosophila  0   *Cyclins *Drosophila Proteins. Genetics 2010 Apr;184(4):1025-35
Pcl9 protein, S cerevisiae  0   *Cyclins *Saccharomyces cerevisiae Proteins. Mol Cell Biol 1997 Mar;17(3):1212-23
cyclin J, Drosophila  0   *Cyclins *Drosophila Proteins. Dev Biol 2009 Sep 15;333(2):263-72
CCNY protein, human  0   *Cyclins. FEBS Lett 2009 Jul 7;583(13):2171-8
cyclin X, human  0   *Cyclins. Mol Biol Rep. 2009 Jan;36(1):97-103
PCL8 protein, S cerevisiae  0   *Cyclins *Saccharomyces cerevisiae Proteins.
PCL10 protein, S cerevisiae  0   *Cyclins *Saccharomyces cerevisiae Proteins.
cyclin O, mouse  0   *Cyclins DNA Glycosylases. Cell Death Differ 2009 Feb;16(2):230-43
FAM58A protein, human  0   *Cyclins. Nat Genet 2008 Mar;40(3):287-9
cyclin E2, Xenopus  0   *Cyclins *Xenopus Proteins. Dev Biol 2007 Oct 15;310(2):341-7
ccndx protein, Xenopus  0   *Cyclins *Xenopus Proteins Nerve Tissue Proteins. EMBO Rep. 2007 Mar;8(3):287-92
Pcl7 protein, S cerevisiae  0   *Cyclins *Saccharomyces cerevisiae Proteins Nuclear Proteins. Mol Biol Cell 2006 Jul;17(7):2952-62
CYCD3;1 protein, Arabidopsis  0   *Cyclins *Arabidopsis Proteins. Plant Cell 2003 Sep;15(9):1951-61
pas1 protein, S pombe  0   *Cyclins *Schizosaccharomyces pombe Proteins.
Ccnl1 protein, rat  0   *Cyclins. Mol Cell Biol 2006 Apr;26(7):2736-45
BME2 protein, Arabidopsis  0   *Transcription Factors *Arabidopsis Proteins Cyclins Zinc Fingers. Plant J 2005 Dec;44(6):960-71
Ccne2 protein, mouse  0   *Cyclins.
CCNE2 protein, human  0   *Cyclins.
Ccnf protein, rat  0   *Cyclins.
Ccnf protein, mouse  0   *Cyclins.
CCNF protein, human  0   *Cyclins.
Rem1 protein, S pombe  0   *Cyclins. Mol Cell 2005 May 13;18(4):491-8
Ccnl2 protein, mouse  0   *Cyclins.
Ccnl protein, rat  0   *Cyclins.
cyclin H1, Arabidopsis  0   *Cyclins *Arabidopsis Proteins. Plant Cell 2004 Nov;16(11):2954-66
CycD3 protein, Arabidopsis  0   *Cyclins *Arabidopsis Proteins. J Exp Bot. 2005 Jan;56(409):123-34
Mcs2 protein, S pombe  0   *Cyclins *Schizosaccharomyces pombe Proteins. Biochem Biophys Res Commun 2004 Dec 24;325(4):1424-32
YHC3 protein, S cerevisiae  0   *Cyclins *Saccharomyces cerevisiae Proteins.
PHO80-like protein, Arabidopsis  0   *Repressor Proteins *Cyclins *Arabidopsis Proteins. Cell Mol Life Sci 2004 Jun;61(12):1485-97
CABLES1 protein, human  0   *Carrier Proteins *Phosphoproteins *Cyclins.
ccnd2-A protein, Xenopus  0   *Cyclins *Xenopus Proteins.
CycD2 protein, Arabidopsis  0   *Cyclins *Arabidopsis Proteins.
K cyclin protein, Herpesvirus 8, Human  0   *Cyclins *Viral Proteins. Cancer Res 2004 Jan 15;64(2):581-9
CCNL2 protein, human  0   *Transcription Factors *Cyclins. J Biol Chem. 2004 Feb 6;279(6):4612-24
D-type cyclin CDCD4.1, Arabidopsis  0   *Cyclins. Plant Physiol 2003 Jul;132(3):1315-21
Cyc6 protein, Trypanosoma brucei  0   *Cyclins. J Biol Chem 2003 Jun 20;278(25):22877-86
CCNL1 protein, human  0   *Cyclins. Cancer Res. 2002 Nov 1;62(21):(6211-7)
solo dancers protein, Arabidopsis  0   *Cyclins *Arabidopsis Proteins. EMBO J 2002 Jun 17;21(12):3081-95
PCL5 protein, S cerevisiae  0   *Cyclins *Saccharomyces cerevisiae Proteins. Mol Cell Biol 2002 Aug;22(15):5395-404
Ccnl1 protein, mouse  0   *Cyclins. Neuron 2001 Oct 25;32(2):277-87
cyclin B5 protein, Xenopus  0   *Cyclins *Xenopus Proteins. Development 2001 Oct;128(19):3795-807
cyclin B4 protein, Xenopus  0   *Cyclins *Xenopus Proteins. Development 2001 Oct;128(19):3795-807
FIC1 protein, Gibberella moniliformis  0   *Fungal Proteins *Cyclins. Appl Environ Microbiol 2001 Apr;67(4):1607-12
PclA protein, Aspergillus  0   *Fungal Proteins Cyclins. Mol Cell Biol 2001 Jun;21(12):4075-88
Bur2 protein, S cerevisiae  0   *Cyclins *Saccharomyces cerevisiae Proteins. Mol Cell Biol 2000 Oct;20(19):7080-7
Cables1 protein, mouse  0   *Carrier Proteins *Phosphoproteins *Cyclins. Biochem Biophys Res Commun 2000 Jul 5;273(2):442-7; Neuron 2000 Jun;26(3):633-46
M cyclin, gamma-herpesvirus 68  0   *Viral Proteins *Cyclins. EMBO J 2000 Jun 15;19(12):2877-88
PfPK5 protein, Plasmodium falciparum  0   *Cyclins *Protozoan Proteins. J Biol Chem 2000 Mar 24;275(12):8952-8
Cyc3 protein, Trypanosoma brucei  0   *Protozoan Proteins *Cyclins. J Biol Chem 2000 Mar 24;275(12):8315-23
GTcyc protein, Nicotiana  0   *Plant Proteins *Cyclins. Biochim Biophys Acta 1999 Dec 23;1489(2-3):399-404
cyc2 protein, Paramecium tetraurelia  0   *Protozoan Proteins *Cyclins. J Eukaryot Microbiol 1999 Nov-Dec;46(6):585-96
cyc1 protein, Paramecium tetraurelia  0   *Protozoan Proteins *Cyclins. J Eukaryot Microbiol 1999 Nov-Dec;46(6):585-96
CTDK-I protein complex, S cerevisiae  0   *Protein Kinases *Saccharomyces cerevisiae Proteins Cyclins. Mol Cell Biol 1999 Apr;19(4):2527-34
HHV8-Vcyc protein, Human herpesvirus 8  0   *Viral Proteins Cyclins. J Virol 1997 Mar;71(3):1984-91
CCNK protein, human  0   *Cyclins. Mol Cell Biol 1998 Jul;18(7):4291-300
Pch1 protein, S pombe  0   *Cyclins *Schizosaccharomyces pombe Proteins. J Biol Chem 1997 May 2;272(18):12100-6
Gak protein, rat  0   *Cyclins *Protein-Serine-Threonine Kinases. FEBS Lett 1997 Jan 27;402(1):73-80
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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