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Alkyl and Aryl Transferases

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Definition: A somewhat heterogeneous class of enzymes that catalyze the transfer of alkyl or related groups (excluding methyl groups). EC 2.5.     
Examples Cysteine Synthase; 3-Deoxy-7-Phosphoheptulonate Synthase; Dihydropteroate Synthase; Dimethylallyltranstransferase; Farnesyl-Diphosphate Farnesyltransferase; Farnesyltranstransferase; Geranylgeranyl-Diphosphate Geranylgeranyltransferase; Geranyltranstransferase; Glutathione Transferase; Hydroxymethylbilane Synthase; Methionine Adenosyltransferase; 3-Phosphoshikimate 1-Carboxyvinyltransferase; Riboflavin Synthase; Spermidine Synthase; Spermine Synthase 		Other names Aryltransferases; Alkyltransferases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
homogentisate geranylgeranyl transferase, Hordeum vulgare  EC 2.5.-   *Alkyl and Aryl Transferases. Plant J. 2011 Jan;65(2):206-17.
coenzyme Q biosynthesis protein 2, Drosophila  EC 2.5.-   *Alkyl and Aryl Transferases *Drosophila Proteins. J Genet Genomics 2011 Jun 20;38(6):225-34
PPPS protein, Arabidopsis  EC 2.5.-   *Alkyl and Aryl Transferases *Arabidopsis Proteins. Plant Physiol 2011 Mar;155(3):1079-90
heme O synthase, Trypanosoma cruzi  EC 2.5.1.-   *Protozoan Proteins *Alkyl and Aryl Transferases. FEMS Microbiol Lett. 2010 Nov;312(2):133-41
prenyl diphosphate synthase, subunit 2, human  EC 2.5.1.-   *Alkyl and Aryl Transferases. Anticancer Drugs 2009 Feb;20(2):141-8
quinolinate synthase, E coli  EC 2.5.-   *Alkyl and Aryl Transferases *Escherichia coli Proteins. FEBS Lett 2008 Aug 20;582(19):2937-44
DesVI protein, Streptomyces venezuelae  EC 2.5.1.-   *Alkyl and Aryl Transferases. Biochemistry 2008 Apr 1;47(13):3982-8
homogentisate solanesyltransferase, Arabidopsis  EC 2.5.1.-   *Alkyl and Aryl Transferases *Arabidopsis Proteins. Planta 2007 Sep;226(4):1067-73
agmatine-cadaverine aminopropyl transferase, Pyrococcus furiosus  EC 2.5.-   *Archaeal Proteins *Alkyl and Aryl Transferases. J Bacteriol 2007 Aug;189(16):6057-67
prenyldiphosphate synthase, subunit 1, human  EC 2.5.1.-   *Alkyl and Aryl Transferases. J Clin Invest 2007 Mar;117(3):765-72
dammarenediol-II synthase, Panax ginseng  EC 2.5.1.-   *Alkyl and Aryl Transferases. FEBS Lett 2006 Oct 2;580(22):5143-9
COX10 protein, mouse  EC 2.5.1.-   *Membrane Proteins *Alkyl and Aryl Transferases. Mol Cell Biol. 2006 Jul;26(13):4872-81
Srt1 protein, S cerevisiae  EC 2.5.-   *Alkyl and Aryl Transferases *Saccharomyces cerevisiae Proteins. Mol Cell Biol 1999 Jan;19(1):471-83
germacrene A synthase, Artemisia annua  EC 2.5.1.-   *Alkyl and Aryl Transferases. Arch Biochem Biophys 2006 Apr 15;448(1-2):3-12
ATL1 protein, S pombe  EC 2.5.-   *Alkyl and Aryl Transferases. Nucleic Acids Res 2006;34(8):2347-54
thiamine phosphate synthase, Plasmodium falciparum  EC 2.5.-   *Alkyl and Aryl Transferases. Biol Chem 2006 Jan;387(1):41-51
germacrene A synthase, Ixeris dentata  EC 2.5.1.-   *Alkyl and Aryl Transferases. Biotechnol Lett 2005 Mar;27(5):285-8
alkyltransferase-like protein, E coli  EC 2.5.1.-   *Alkyl and Aryl Transferases *Escherichia coli Proteins DNA Repair. Nucleic Acids Res. 2005;33(12) (dup#5):3837-44
SPS2 protein, Arabidopsis  EC 2.5.1.11   *Alkyl and Aryl Transferases *Arabidopsis Proteins. Plant Cell Physiol 2004 Dec;45(12):1882-8
SPS1 protein, Arabidopsis  EC 2.5.1.11   *Alkyl and Aryl Transferases *Arabidopsis Proteins. Plant Cell Physiol 2004 Dec;45(12):1882-8
1,4-dihydroxy-2-naphthoic acid phytyltransferase, Arabidopsis  EC 2.5.-   *Alkyl and Aryl Transferases *Arabidopsis Proteins. Plant J 2005 Feb;41(4):627-37
Rv2361c protein, Mycobacterium tuberculosis  EC 2.5.1.-   *Bacterial Proteins *Alkyl and Aryl Transferases.
syn-pimara-7,15-diene synthase, Oryza sativa  EC 2.5.1.-   *Plant Proteins *Alkyl and Aryl Transferases. Plant Physiol 2004 Aug;135(4):2098-105
COX10 protein, human  EC 1.9.3.1   *Electron Transport Complex IV *Membrane Proteins *Alkyl and Aryl Transferases.
CyoE protein, E coli  EC 2.5.1.-   *Alkyl and Aryl Transferases *Escherichia coli Proteins.
BET2 protein, S cerevisiae  EC 2.5.1.-   *Alkyl and Aryl Transferases *Saccharomyces cerevisiae Proteins.
BET4 protein, S cerevisiae  EC 2.5.1.60   *Alkyl and Aryl Transferases *Saccharomyces cerevisiae Proteins.
Geranylgeranyltransferase type II  EC 2.5.1.-   *Alkyl and Aryl Transferases.
ptb1 protein, S pombe  0   *Alkyl and Aryl Transferases *Schizosaccharomyces pombe Proteins Protein Prenylation.
isopentenyl-dimethylallyl diphosphate synthase, Nicotiana benthamiana  EC 2.5.1.-   *Alkyl and Aryl Transferases. Plant Physiol 2004 Apr;134(4):1401-13
(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase, Nicotiana benthamiana  EC 2.5.1.-   *Alkyl and Aryl Transferases. Plant Physiol 2004 Apr;134(4):1401-13
valencene synthase, Citrus  EC 2.5.1.-   *Plant Proteins *Alkyl and Aryl Transferases. Plant J 2003 Dec;36(5):664-74
SLY1 protein, Arabidopsis  EC 2.5.1.29   *Alkyl and Aryl Transferases *Arabidopsis Proteins. Plant Cell 2003 May;15(5):1120-30
(+)-3-carene synthase, Picea abies  EC 2.5.1.-   *Alkyl and Aryl Transferases. Plant Mol Biol 2003 Jan;51(1):119-33
germacrene D synthase  EC 2.5.1.-   *Alkyl and Aryl Transferases Sesquiterpenes, Germacrane. Plant Cell 2002 Oct;14(10):2325-38
germacrene A synthase, Cichorium intybus  EC 2.5.1.-   *Plant Proteins *Alkyl and Aryl Transferases Sesquiterpenes, Germacrane. Plant Physiol 2002 May;129(1):134-44
geranyl diphosphate 4-hydroxybenzoate geranyltransferase  EC 2.5.1.-   *Alkyl and Aryl Transferases. J Biol Chem 2002 Feb 22;277(8):6240-6
HPT1 protein, Arabidopsis  EC 2.5.-   *Alkyl and Aryl Transferases *Arabidopsis Proteins. Plant Physiol 2001 Nov;127(3):1113-24
thiamin phosphate synthase  EC 2.5.-   *Alkyl and Aryl Transferases. Biochemistry 2001 Aug 28;40(34):10095-102
levopimaradiene synthase  EC 2.5.1.-   *Alkyl and Aryl Transferases. Arch Biochem Biophys 2001 Aug 15;392(2):263-9
aphidicolan-16beta-ol synthase  EC 2.5.1.-   *Alkyl and Aryl Transferases. J Am Chem Soc 2001 May 30;123(21):5154-5
dimethylallyl diphosphate naringenin 8-dimethylallyltransferase  EC 2.5.1.-   *Alkyl and Aryl Transferases. Phytochemistry 2000 Aug;54(7):649-55
CarRP protein, Mucor circinelloides  0   *Fungal Proteins *Multienzyme Complexes *Intramolecular Lyases *Alkyl and Aryl Transferases. Eur J Biochem 2000 Sep;267(17):5509-19
phytyltransferase  EC 2.5.-   *Alkyl and Aryl Transferases. J Biol Chem 2000 Mar 24;275(12):8523-30
Rv1086 protein, Mycobacterium tuberculosis  EC 2.5.1.-   *Bacterial Proteins *Alkyl and Aryl Transferases. J Biol Chem 2000 Jul 28;275(30):22876-81
amorpha-4,11-diene synthase  EC 2.5.1.-   *Alkyl and Aryl Transferases. Phytochemistry 1999 Nov;52(5):843-54
BIM 46050  0   *Amino Acids, Cyclic Alkyl and Aryl Transferases/antagonists & inhibitors. Int J Cancer 1999 Oct 8;83(2):283-7
BIM 46068  0   *Amino Acids, Cyclic Alkyl and Aryl Transferases/antagonists & inhibitors. Int J Cancer 1999 Oct 8;83(2):283-7
estrone oxime 3-O-sulfamate  0   *Oximes Estrone Alkyl and Aryl Transferases. J Med Chem 1999 Aug 12;42(16):3188-92
nicotianamine synthase  EC 2.5.-   *Alkyl and Aryl Transferases. Plant Physiol 1999 Feb;119(2):471-9
S-(1,2-dicarboxyethyl)glutathione synthetase  EC 2.5.1.-   *Alkyl and Aryl Transferases. Biol Pharm Bull 1999 Jan;22(1):21-5
CPS protein, Gibberella fujikuroi  EC 2.5.1.-   *Fungal Proteins *Alkyl and Aryl Transferases Terpenes. Curr Genet 1998 Sep;34(3):234-40
BTH1 protein, Brassica napus  EC 2.-   *Multienzyme Complexes *Plant Proteins *Phosphotransferases (Phosphate Group Acceptor) *Alkyl and Aryl Transferases. Plant Mol Biol 1998 Aug;37(6):955-66
(E)-alpha-bisabolene synthase  EC 2.5.1.-   *Alkyl and Aryl Transferases Sesquiterpenes. Proc Natl Acad Sci U S A 1998 Jun 9;95(12):6756-61
geranylpyrophosphate olivetolate geranyltransferase  EC 2.5.1.-   *Alkyl and Aryl Transferases. FEBS Lett 1998 May 8;427(2):283-5
MenA protein, E coli  EC 2.5.1.-   *Alkyl and Aryl Transferases *Escherichia coli Proteins. J Bacteriol 1998 May;180(10):2782-7
germacrene C synthase  EC 2.5.1.-   *Alkyl and Aryl Transferases Sesquiterpenes, Germacrane. Proc Natl Acad Sci U S A 1998 Mar 3;9595):2216-21
delta-selinene synthase  EC 2.5.1.-   *Alkyl and Aryl Transferases Sesquiterpenes. J Biol Chem 1998 Jan 23;273(4):2078-89
gamma-humulene synthase  EC 2.5.1.-   *Alkyl and Aryl Transferases Sesquiterpenes. J Biol Chem 1998 Jan 23;273(4):2078-89
terpene synthase  EC 2.5.1.-   *Alkyl and Aryl Transferases Arabidopsis Proteins. Gene 1997 Oct 15;199(1-2):241-53
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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