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Intramolecular Lyases

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Definition: Enzymes of the isomerase class that catalyze reactions in which a group can be regarded as eliminated from one part of a molecule, leaving a double bond, while remaining covalently attached to the molecule. (From Enzyme Nomenclature, 1992) EC 5.5.     
Examples Myo-Inositol-1-Phosphate Synthase 		Other names Lyases, Intramolecular
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
TPSO3 protein, Arabidopsis  EC 5.5.-   *Multienzyme Complexes *Pyrophosphatases *Intramolecular Lyases *Arabidopsis Proteins. Plant Physiol 2010 Jul;153(3):1293-310
TPSO2 protein, Arabidopsis  EC 5.5.-   *Multienzyme Complexes *Pyrophosphatases *Intramolecular Lyases *Arabidopsis Proteins. Plant Physiol 2010 Jul;153(3):1293-310
NisC protein, E coli  EC 5.5.-   *Intramolecular Lyases *Escherichia coli Proteins. J Biol Chem 2007 Jul 20;282(29):21169-75
CarRP protein, Mucor circinelloides  0   *Fungal Proteins *Multienzyme Complexes *Intramolecular Lyases *Alkyl and Aryl Transferases. Eur J Biochem 2000 Sep;267(17):5509-19
cycloeucalenol cycloisomerase  EC 5.5.1.-   *Intramolecular Lyases. J Biol Chem 2000 May 5;275(18):13394-7
TPS10 protein, Arabidopsis  EC 5.5.-   *Intramolecular Lyases *Arabidopsis Proteins Monoterpenes. J Biol Chem 1997 Aug 29;272(35):21784-92
streptogramin B lyase  EC 5.5.1.-   *Intramolecular Lyases. Anal Biochem 1997 Jun 1;248(2):297-9
D-myo-inositol-3-phosphate synthase  EC 5.5.1.-   *Intramolecular Lyases. Plant Mol Biol 1997 Mar;33(5):811-20
lycopene cyclase-isomerase  EC 5.5.-   *Intramolecular Lyases. J Biol Chem 1991;266(26):17072
dichloromuconate cycloisomerase  EC 5.5.1.11   *Intramolecular Lyases. J Biochem 1990;266(3):877
geranyl pyrophosphate-sabinene hydrate cyclase  EC 5.5.-   *Intramolecular Lyases. Arch Biochem Biophys 1988;264(2):618
chloromuconate cycloisomerase  EC 5.5.1.7   *Intramolecular Lyases. J Bacteriol 1988;170(5):2412
farnesylpyrophosphate cyclase  EC 5.5.-   *Intramolecular Lyases. J Antibiot (Tokyo) 1986;39(2):266
endo-fenchol cyclase  EC 5.5.-   *Intramolecular Lyases. J Biol Chem 1985;260(26):13901
geranyl-diphosphate cyclase  EC 5.5.1.8   *Intramolecular Lyases. Arch Biochem Biophys 198(2):512;1979; Arch Biochem Biophys 1985;236(2):535
pinene cyclase I  EC 5.5.-   *Intramolecular Lyases. J Biol Chem 1984;259(2):740
muconate cycloisomerase  EC 5.5.1.1 4-carboxy- methyl-4-hydroxyisocrotonolactone lyase(decycling)  *Intramolecular Lyases. J Bacteriol 124(2):679;1975; J Mol Biol 89(4):651;1974
2-methylmuconic acid cycloisomerase  EC 5.5.1.-   *Intramolecular Lyases. Biochem J 174(1):76;1978
chalcone isomerase  EC 5.5.1.6   *Intramolecular Lyases Flavanones Chalcones. Arch Biochem Biophys 166(1):41;1975; Biochim Biophys Acta 399(1):23;1975
3-carboxy-cis-cis-muconate cyclase  EC 5.5.1.5   *Intramolecular Lyases. Eur J Biochem 48(2):549;1974; Eur J Biochem 56(1):193;1975
3-carboxy-cis-cis-muconate cycloisomerase  EC 5.5.1.2   *Intramolecular Lyases.

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