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Nuclear Receptor Coactivators

More information in Books or onNLM PubMed
Definition: Proteins that enhance gene expression when associated with ligand bound activated NUCLEAR RECEPTORS. The coactivators may act through an enzymatic process that affects the rate of transcription or the structure of chromatin. Alternatively nuclear receptor coactivators can function as adaptor proteins that bring nuclear receptors into close proximity with transcriptional complexes.     
Examples Mediator Complex Subunit 1; Nuclear Receptor Coactivator 1; Nuclear Receptor Coactivator 2; Nuclear Receptor Coactivator 3
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NcoA4 protein, mouse  0   *Nuclear Receptor Coactivators. J Cell Physiol 2006 Jan;206(1):255-63
Ncoa6 protein, rat  0   *Nuclear Receptor Coactivators.
NCOA6 protein, human  0   *Nuclear Receptor Coactivators.
NCOA7 protein, human  0   *Nuclear Receptor Coactivators. Mol Cell Biol 2002 May;22(10):3358-72
NCOA5 protein, human  0   *Nuclear Receptor Coactivators. Mol Cell Biol 2001 Jan;21(1):343-53
Ncoa6 protein, mouse  0   *Nuclear Receptor Coactivators. J Biol Chem 2000 Feb 25;275(8):5308-17
SNW1 protein, human  0   *Nuclear Receptor Coactivators. J Biol Chem 1998 Jun 26;273(26):16434-41; Oncogene 1998 Mar 26;16(12):1579-86
NCOA4 protein, human  0   *Nuclear Receptor Coactivators. Br J Cancer 1998 Mar;77(6):903-6; Proc Natl Acad Sci U S A 1996 May 28;93(11):5517-21

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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