Definition: A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS and PROGESTERONE RECEPTORS. It contains a histone acetyltransferase activity that may play a role in CHROMATIN REMODELING during the process of nuclear receptor-induced transcription. The coactivator has been found at elevated levels in certain HORMONE-DEPENDENT NEOPLASMS such as those found in BREAST CANCER.
Other names Receptor Associated Coactivator 3; Amplified in Breast Cancer 1 Protein; Thyroid Hormone Receptor Activator Molecule 1; Steroid Receptor Coactivator 3; Receptor-Associated Coactivator 3; Amplified in Breast Cancer-1 Protein; Nuclear Receptor Coactivator-3