Interferon-Stimulated Gene Factor 3 (definition)

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Interferon-Stimulated Gene Factor 3

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Definition: A multimeric complex that functions as a ligand-dependent transcription factor. ISGF3 is assembled in the CYTOPLASM and translocated to the CELL NUCLEUS in response to INTERFERON signaling. It consists of ISGF3-GAMMA and ISGF3-ALPHA, and it regulates expression of many interferon-responsive GENES.

Examples Interferon-Stimulated Gene Factor 3, alpha Subunit; Interferon-Stimulated Gene Factor 3, gamma Subunit

Other names Transcription Factor, ISGF3; Interferon Stimulated Gene Factor 3; ISGF3, Transcription Factor; IFN Stimulated Gene Factor 3 Complex; Transcription Factor ISGF3; ISGF3 Factor; ISGF3 Transcription Factor; IFN-Stimulated Gene Factor 3 Complex

Substance	CAS Registry & name	Categories	Source	Drugs*
gamma interferon activation factor	0	*Interferon-Stimulated Gene Factor 3 DNA-Binding Proteins STAT1 Transcription Factor.	Mol Cell Biol 1993 Mar;13(3):1634-40

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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