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Mediator Complex

More information in Books or onNLM PubMed
Definition: A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.     
Examples Cyclin C; Cyclin-Dependent Kinase 8; Mediator Complex Subunit 1 		Other names Thyroid Hormone Associated Protein Complex; Mediator Like Complexes; Mediator Like Complex; Thyroid Hormone-Associated Protein Complex; TRAP (Thyroid Hormone Associated Protein) Complex; TR-Associated Protein (TRAP) Complex; Mediator-Like Complexes; Mediator-Like Complex; Mediator Transcription Complex
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MDT-15 protein, C elegans  0   *Transcription Factors *Caenorhabditis elegans Proteins Protein Subunits Mediator Complex. PLoS One. 2011;6(11):e28036.
Med30 protein, mouse  0   *Mediator Complex. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49); 19678-82
MED19 protein, human  0   *Mediator Complex. Oncol Res. 2011;19(5):193-201
MED31 protein, mouse  0   *Mediator Complex Protein Subunits. Dev Biol 2010 Jun 15;342(2):146-56
Med23 protein, mouse  0   *Mediator Complex. Dev Cell 2009 May;16(5):764-71
Med12 protein, mouse  0   *Mediator Complex. J Biol Chem 2009 Feb 6;284(6):3709-18
MED31 protein, human  0   *Mediator Complex.
Med17 protein, human  0   *Mediator Complex.
MED16 protein, human  0   *Mediator Complex.
MED10 protein, human  0   *Mediator Complex.
Med11 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. Mol Cell 2008 Aug 8;31(3):337-46
Med31 protein, Drosophila  0   *Drosophila Proteins *Mediator Complex. Dev Biol 2008 Jan 15;313(2):802-13
Med13 protein, mouse  0   *Mediator Complex. Science 2007 Apr 27;316(5824):575-9
MED29 protein, human  0   *Mediator Complex. Biochem Biophys Res Commun 2004 Dec 24;325(4):1330-8
Crsp150 protein, zebrafish  0   *Zebrafish Proteins *Mediator Complex. Genetics 2006 Oct;174(2):693-705
crsp8 protein, zebrafish  0   *Zebrafish Proteins *Mediator Complex. Genetics 2006 Oct;174(2):693-705
Med12 protein, zebrafish  0   *Zebrafish Proteins *Mediator Complex. Proc Natl Acad Sci U S A 2005 Dec 20;102(51):18473-8
MED24 protein, human  0   *Mediator Complex.
MED28 protein, human  0   *Mediator Complex. Oncogene 2004 Nov 18;23(54);8815-25
Med31 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. Nucleic Acids Res 2004;32(18):5379-91
MED14 protein, human  0   *Mediator Complex.
MED23 protein, human  0   *Mediator Complex.
MED26 protein, human  0   *Mediator Complex.
MED27 protein, human  0   *Mediator Complex.
MED7 protein, human  0   *Mediator Complex.
MED4 protein, human  0   *Mediator Complex.
Med6 protein, Drosophila  0   *Drosophila Proteins *Mediator Complex.
MED6 protein, human  0   *Mediator Complex.
Med13l protein, mouse  0   *Mediator Complex. Gene 2004 May 12;332:119-27
MED13 protein, human  0   *Mediator Complex. J Biol Chem 2004 Jul 9;279(28):29270-7
MED22 protein, human  0   *Mediator Complex.
MED25 protein, human  0   *Mediator Complex. J Biol Chem 2004 Feb 13;279(7):5846-51
MED8 protein, human  0   *Mediator Complex. J Biol Chem 2003 Dec 12;278(50):49671-4
MED13L protein, human  0   *Mediator Complex. Circulation 2003 Dec 9;108(23);2843-50
MED17 protein, Drosophila  0   *Drosophila Proteins *Mediator Complex. Mol Cell Biol 2003 Feb;23(4):1358-67
MED2 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. Mol Cell Biol 2003 Jan;23(1):349-58
MED8 protein, rat  0   *Mediator Complex. Proc Natl Acad Sci U S A 2002 Aug 6;99(16):10353-8
MED12 protein, human  0   *Mediator Complex. Am J Med Genet 2002 Jan 8;114(1):110-5
pmc4 protein, S pombe  0   *Schizosaccharomyces pombe Proteins *Mediator Complex. Proc Natl Acad Sci U S A 2001 Oct 9;98(21):11985-90
MED8 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. Curr Genet 2000 Dec;38(5):227-32
MED15 protein, human  0   *Mediator Complex. Am J Med Genet. 2003 Jan 1;116B(1):32-5; Gene 2000 Sep 19;255(2):389-400; Genomics 2001 Jun 15;74(3):320-32
Med24 protein, mouse  0   *Mediator Complex. Mol Endocrinol 1999 Jul;13(7):1130-40
NUT2 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. Mol Cell Biol 1998 Aug;18(8):4707-18
NUT1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. Mol Cell Biol 1998 Aug;18(8):4707-18
PGD1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. Genetics 1996 Mar;142(3):705-16
MED7 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. Genes Dev 1998 Jan 1;12(1):45-54
MED6 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. Mol Cell Biol 1997 Aug;17(8):4622-32
ROX3 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. J Biol Chem 1997 Jan 3;272(1):48-50
MED21 protein, human  0   *Mediator Complex. Nature 1996 Mar 7;380(6569):82-5
RGR1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. Genetics 1995 May;140(1):47-54
SSN2 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. Genes Dev 1995 Apr 15;9(8):897-910
SRB7 protein, S cerevisiae  0   *Mediator Complex *Saccharomyces cerevisiae Proteins. Genes Dev 1995 Apr 15;9(8):897-910
CSE2 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. Mol Cell Biol 1993 Aug;13(8):4691-702
SRB6 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. Cell 1993 Jul 2;73(7):1361-75
SRB5 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. Cell 1993 Jul 2;73(7):1361-75
SRB4 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. Cell 1993 Jul 2;73(7):1361-75
SIN4 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. Mol Cell Biol 1992 Oct;12(10):4503-14
SRB2 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. Cell 1992 May 29;69(5):883-94
GAL11 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Mediator Complex. Mol Cell Biol 1988;8(11):4991

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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