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GRB2 Adaptor Protein

More information in Books or onNLM PubMed
Definition: A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).      Other names Growth Factor Receptor Bound Protein 2; GRB2 Adaptor Protein, Grb3 3 Isoform; Grb3-3 Adaptor Protein; GRB2 Adaptor Protein, Grb3-3 Isoform; Abundant Src Homology Protein; Growth Factor Receptor-Bound Protein-2
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
GAREM protein, human  0   *GRB2 Adaptor Protein. J Biol Chem. 2009 Jul 24;284(30):20206-14
cyclo(CH2-CO-gamma-carboxylglutamyl-leucyl-(3'-aminotyrosyl)-Ac6c-asparaginyl-(5-aminovalyl)-cysteinyl(O))-amide  0   *Peptides, Cyclic GRB2 Adaptor Protein/antagonists & inhibitors. J Med Chem 2006 Mar 9;49(5):1585-96
Grb2 protein, rat  0   *GRB2 Adaptor Protein.
Grb2 protein, mouse  0   *GRB2 Adaptor Protein.
GRB2 protein, human  0   *GRB2 Adaptor Protein.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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