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Interferon Regulatory Factors

More information in Books or onNLM PubMed
Definition: A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression. IRF proteins bind specific DNA sequences such as interferon-stimulated response elements, interferon regulatory elements, and the interferon consensus sequence.     
Examples Interferon Regulatory Factor-1; Interferon Regulatory Factor-2; Interferon Regulatory Factor-3; Interferon Regulatory Factor-7; Interferon-Stimulated Gene Factor 3, gamma Subunit 		Other names Transcription Factors, IRF; IRF Transcription Factors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
IRF7 protein, zebrafish  0   *Zebrafish Proteins *Interferon Regulatory Factors. Dev Comp Immunol 2010 Dec;34(12):1263-73
IRF5 protein, zebrafish  0   *Zebrafish Proteins *Interferon Regulatory Factors. Dev Comp Immunol 2010 Dec;34(12):1263-73
IRF6 protein, mouse  0   *Interferon Regulatory Factors. Dev Dyn 2006 May;235(5):1441-7
CRISPLD2 protein, human  0   *Cell Adhesion Molecules *Interferon Regulatory Factors. Hum Mol Genet. 2007 Sep 15;16(18):2241-8
IRF6 protein, zebrafish  0   *Zebrafish Proteins *Interferon Regulatory Factors DNA-Binding Proteins Helix-Turn-Helix Motifs. Gene Expr Patterns 2005 Jun;5(5):629-38
Irf5 protein, mouse  0   *Interferon Regulatory Factors. Nature 2005 Mar 10;434(7030):243-9
xIRF-6 protein, Xenopus  0   *Xenopus Proteins *Interferon Regulatory Factors.
interferon regulatory factor-10, Gallus gallus  0   *Avian Proteins *Interferon Regulatory Factors. Mol Cell Biol 2002 Jun;22(11):3942-57
IRF4 protein, Gallus gallus  0   *Avian Proteins *Interferon Regulatory Factors. Mol Cell Biol 2001 Oct;21(19):6369-86
IRF5 protein, human  0   *Interferon Regulatory Factors. interferon regulatory factor 5623-55
viral interferon regulatory factors  0   *Viral Proteins *Interferon Regulatory Factors Repressor Proteins. J Virol 2000 Sep;74(18):8623-34
interferon regulatory factor, flounder  0   *Fish Proteins *Interferon Regulatory Factors. Mol Mar Biol Biotechnol 1998 Jun;7(2):138-44
IRF6 protein, human  0   *Interferon Regulatory Factors. Gene 1997 Dec 12;203(2):183-8
IRF-3 protein, Gallus gallus  0   *Avian Proteins *Interferon Regulatory Factors. Nucleic Acids Res 1995 Jun 25;23(12):2137-46
interferon regulatory factor-4  0   *Interferon Regulatory Factors. Nucleic Acids Res 1995 Jun 25;23(12):2127-36
interferon regulatory factor-8  0   *Interferon Regulatory Factors Interferons Consensus Sequence. Proc Natl Acad Sci USA 1990;87(10):3743

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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