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Suppressor of Cytokine Signaling Proteins

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Definition: A family of structurally related proteins that are induced by CYTOKINES and negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. SOCS proteins contain a central SH2 DOMAIN and a C-terminal region of homology known as the SOCS box.      Other names Suppressors of Cytokine Signaling Proteins; SOCS Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SOCS6 protein, rat  0   *Suppressor of Cytokine Signaling Proteins. Diabetes. 2008 Jun;57(6):1651-8.
SOCS3 protein, zebrafish  0   *Zebrafish Proteins *Suppressor of Cytokine Signaling Proteins. Gen Comp Endocrinol 2009 Mar;161(1):67-72
SOCS1 protein, zebrafish  0   *Zebrafish Proteins *Suppressor of Cytokine Signaling Proteins. Gen Comp Endocrinol 2009 Mar;161(1):67-72
ASB9 protein, human  0   *Suppressor of Cytokine Signaling Proteins Ankyrin Repeat. Protein Pept Lett 2009;16(3):333-5
Asb4 protein, mouse  0   *Suppressor of Cytokine Signaling Proteins. Mol Cells 2008 Apr 30;25(2):317-21
Wsb1 protein, zebrafish  0   *Zebrafish Proteins *Suppressor of Cytokine Signaling Proteins. Acta Biochim Biophys Sin (Shanghai) 2008 Jun;40(6):478-88
SOCS5 protein, rat  0   *Suppressor of Cytokine Signaling Proteins. Mol Cells 2007 Feb 28;23(1):94-9
Wsb-2 protein, mouse  0   *Suppressor of Cytokine Signaling Proteins. Oncogene. 2007 Mar 29;26(14):1985-94
Asb-9 protein, mouse  0   *Suppressor of Cytokine Signaling Proteins. J Biol Chem 2007 Feb 16;282(7):4728-37
SSB-4 protein, mouse  0   *Suppressor of Cytokine Signaling Proteins. Reproduction 2006 May;131(5):905-15
SSB-1 protein, mouse  0   *Suppressor of Cytokine Signaling Proteins. Reproduction 2006 May;131(5):905-15
Asb11 protein, zebrafish  0   *Zebrafish Proteins *Suppressor of Cytokine Signaling Proteins. J Cell Biol 2006 Aug 14;174(4):581-92
SOCS7 protein, mouse  0   *Suppressor of Cytokine Signaling Proteins. J Clin Invest 2005 Sep;115(9):2462-71
ASB3 protein, human  0   *Suppressor of Cytokine Signaling Proteins Ankyrin Repeat. Mol Cell Biol 2005 Jun;25(11):4716-26
Asb6 protein, mouse  0   *Suppressor of Cytokine Signaling Proteins Ankyrins. J Biol Chem 2004 Sep 10;279(37):38881-8
Socs1 protein, mouse  0   *Suppressor of Cytokine Signaling Proteins.
Socs1 protein, rat  0   *Suppressor of Cytokine Signaling Proteins.
Socs3 protein, mouse  0   *Suppressor of Cytokine Signaling Proteins Signal Transduction.
Socs3 protein, rat  0   *Suppressor of Cytokine Signaling Proteins Signal Transduction.
Socs2 protein, mouse  0   *Suppressor of Cytokine Signaling Proteins Signal Transduction.
Socs2 protein, rat  0   *Suppressor of Cytokine Signaling Proteins Signal Transduction.
Socs5 protein, mouse  0   *Suppressor of Cytokine Signaling Proteins.
Socs6 protein, mouse  0   *Suppressor of Cytokine Signaling Proteins. APMIS 2002 Dec;110(12):833-44
SOCS6 protein, human  0   *Suppressor of Cytokine Signaling Proteins. APMIS 2002 Dec;110(12):833-44
SOCS4 protein, human  0   *Suppressor of Cytokine Signaling Proteins. APMIS 2002 Dec;110(12):833-44
SOCS4 protein, mouse  0   *Suppressor of Cytokine Signaling Proteins Signal Transduction. J Interferon Cytokine Res 2002 Aug;22(8):853-60
ASB8 protein, human  0   *Suppressor of Cytokine Signaling Proteins Ankyrin Repeat. Biochem Biophys Res Commun 2003 Jan 24;300(4):972-9
Socs36E protein, Drosophila  0   *Drosophila Proteins *Suppressor of Cytokine Signaling Proteins. Oncogene 2002 Jul 18;21(31):4812-21
ASB2 protein, human  0   *Suppressor of Cytokine Signaling Proteins Ankyrin Repeat. Science 2001 Oct 12;294(5541):223-8
Asb1 protein, mouse  0   *Suppressor of Cytokine Signaling Proteins Ankyrin Repeat. Mol Cell Biol 2001 Sep;21(18):6189-97
SOCS5 protein, human  0   *Suppressor of Cytokine Signaling Proteins. Cytogenet Cell Genet 2000 ;88(1-2):78-81
SOCS1 protein, human  0   *Suppressor of Cytokine Signaling Proteins. J Biol Chem 1997 Oct;272(43):27178-82; Nature 1997 Jun 26:387(6636):917-21
SOCS7 protein, human  0   *Nuclear Proteins *Suppressor of Cytokine Signaling Proteins src Homology Domains. Biochem Biophys Res Commun 1997 Oct 20;239(2):488-92
SOCS3 protein, human  0   *Suppressor of Cytokine Signaling Proteins Signal Transduction. Nature 1997 Jun 26;387(6636):917-21
SOCS2 protein, human  0   *Suppressor of Cytokine Signaling Proteins Signal Transduction. Nature 1997 Jun 26;387(6636):917-21
cytokine inducible SH2-containing protein  0   *Suppressor of Cytokine Signaling Proteins Signal Transduction Cytokines src Homology Domains. EMBO J 1995 Jun 15;14(12):2816-26

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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