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Endosomal Sorting Complexes Required for Transport

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Definition: A set of protein subcomplexes involved in PROTEIN SORTING of UBIQUITINATED PROTEINS into intraluminal vesicles of MULTIVESICULAR BODIES and in membrane scission during formation of intraluminal vesicles, during the final step of CYTOKINESIS, and during the budding of enveloped viruses. The ESCRT machinery is comprised of the protein products of Class E vacuolar protein sorting genes.      Other names Machinery, ESCRT; Complexes, ESCRT; Endosomal Sorting Complex Required for Transport M; Endosomal Sorting Complex Required for Transport I; Endosomal Sorting Complex Required for Transport I; Endosomal Sorting Complex Required for Transport I; Endosomal Sorting Complex Required for Transport; ESCRT Machinery; ESCRT III; ESCRT II; ESCRT I; ESCRT Complexes
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
waharan protein, Drosophila  0   *Nuclear Proteins *Vesicular Transport Proteins Endosomal Sorting Complexes Required for Transport. J Cell Sci 2010 Jul 15;123(Pt 14):2369-74
Usp8 protein, mouse  0   *Endopeptidases *Ubiquitin Thiolesterase *Endosomal Sorting Complexes Required for Transport.
USP8 protein, human  0   *Endopeptidases *Ubiquitin Thiolesterase *Endosomal Sorting Complexes Required for Transport. Trends Biochem Sci. 2007 Dec;32(12):561-73
CHMP1B protein, human  0   *Endosomal Sorting Complexes Required for Transport. Trends Biochem Sci. 2007 Dec;32(12):561-73
vacuolar protein sorting 37 homolog B, human  0   *Endosomal Sorting Complexes Required for Transport. Trends Biochem Sci. 2007 Dec;32(12):561-73
Snf7-3 protein, human  0   *Endosomal Sorting Complexes Required for Transport. Arch Biochem Biophys. 2004 Jan 1;421(1):159-65; Trends Biochem Sci. 2007 Dec;32(12):561-73
VPS4 protein, Candida albicans  EC 3.6.1.-   *Fungal Proteins *Virulence Factors *Endosomal Sorting Complexes Required for Transport. Mycopathologia 2009 Feb;167(2):55-63
Vps4 protein, Drosophila  EC 3.6.1.3   *Adenosine Triphosphatases *Drosophila Proteins *Endosomal Sorting Complexes Required for Transport Tumor Suppressor Proteins. PLoS ONE 2009;4(2):e4354
Vps36 protein, Drosophila  0   *Drosophila Proteins *Endosomal Sorting Complexes Required for Transport. PLoS ONE. 2009;4(1) (dup#5):e4165
Vps22 protein, Drosophila  0   *Drosophila Proteins Endosomal Sorting Complexes Required for Transport. PLoS ONE. 2009;4(1) (dup#5):e4165
Vps24 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Endosomal Sorting Complexes Required for Transport. Structure 2008 Sep 10;16(9):1345-56; Trends Biochem Sci. 2007 Dec;32(12):561-73
Sst4 protein, S pombe  0   *Schizosaccharomyces pombe Proteins *Endosomal Sorting Complexes Required for Transport. Eukaryot Cell 2007 Dec;6(12):2343-53
BROX protein, human  0   *Endosomal Sorting Complexes Required for Transport. FEBS J 2008 Feb;275(4):682-92
ALX-1 protein, C elegans  0   *Caenorhabditis elegans Proteins *Endosomal Sorting Complexes Required for Transport. Curr Biol 2007 Nov 20;17(22):1913-24
SNF8 protein, human  0   *Endosomal Sorting Complexes Required for Transport. Traffic 2007 Nov;8(11):1617-29; Trends Biochem Sci. 2007 Dec;32(12):561-73
CHMP2B protein, mouse  0   *Nerve Tissue Proteins *Endosomal Sorting Complexes Required for Transport. Curr Biol 2007 Sep 18;17(18):1561-7
Vps2 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Endosomal Sorting Complexes Required for Transport. Nature 2007 Oct 11;449(7163):735-9; Trends Biochem Sci. 2007 Dec;32(12):561-73
Mvb12 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Endosomal Sorting Complexes Required for Transport. J Cell Biol 2006 Dec 4;175(5):815-23; Trends Biochem Sci. 2007 Dec;32(12):561-73
EAP45 protein, mouse  0   *Endosomal Sorting Complexes Required for Transport Protein Subunits. Nat Struct Mol Biol 2006 Nov;13(11):1031-2
VPS36 protein, human  0   *Endosomal Sorting Complexes Required for Transport Protein Subunits. Nat Struct Mol Biol 2006 Nov;13(11):1029-30; Trends Biochem Sci. 2007 Dec;32(12):561-73
CHMP7 protein, human  0   *Endosomal Sorting Complexes Required for Transport. Biochem J 2006 Nov 15;200(1):23-32
Vps25 protein, Drosophila  0   *Drosophila Proteins *Endosomal Sorting Complexes Required for Transport. Development 2006 May;133(10):1871-80
Vps46 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Endosomal Sorting Complexes Required for Transport. Proc Natl Acad Sci U S A 2006 Apr 18;103(16):6202-7; Trends Biochem Sci. 2007 Dec;32(12):561-73
CHMP5 protein, mouse  0   *Endosomal Sorting Complexes Required for Transport. J Cell Biol 2006 Mar 27;172(7):1045-56
CHMP2A protein, human  0   *Endosomal Sorting Complexes Required for Transport Tumor Markers, Biological. Nucleic Acids Res. 2006;34(2) (dup#5):e13; Trends Biochem Sci. 2007 Dec;32(12):561-73
Chmp2a protein, mouse  0   *Endosomal Sorting Complexes Required for Transport. J Cell Sci. 2004 Jun 15;117(Pt 14):2997-3009
CHMP2B protein, human  0   *Endosomal Sorting Complexes Required for Transport Nerve Tissue Proteins. Nat Genet 2005 Aug;37(8):806-8; Trends Biochem Sci. 2007 Dec;32(12):561-73
VPS37C protein, human  0   *Endosomal Sorting Complexes Required for Transport. J Biol Chem 2005 Jan 7;280(1):628-36; Trends Biochem Sci. 2007 Dec;32(12):561-73
CHMP5 protein, human  0   *Endosomal Sorting Complexes Required for Transport. J Biol Chem 2005 Mar 18;280(11):10548-55; Trends Biochem Sci. 2007 Dec;32(12):561-73
VTA1 protein, human  0   *Endosomal Sorting Complexes Required for Transport. J Biol Chem 2005 Mar 18;280(11):10548-55; Trends Biochem Sci. 2007 Dec;32(12):561-73
CHMP3 protein, human  0   *Endosomal Sorting Complexes Required for Transport. Exp Cell Res. 2005 Mar 10;304(1):265-73; Trends Biochem Sci. 2007 Dec;32(12):561-73
Vps4 protein, Plasmodium falciparum  EC 3.6.1.3   *Adenosine Triphosphatases *Protozoan Proteins *Endosomal Sorting Complexes Required for Transport. J Cell Sci 2004 Aug 1;117(Pt 17):3831-8
VPS37A protein, human  0   *Endosomal Sorting Complexes Required for Transport. Mol Biol Cell 2004 Sep;15(9);4337-46; Trends Biochem Sci. 2007 Dec;32(12):561-73
Stam protein, mouse  0   *Phosphoproteins *Adaptor Proteins, Signal Transducing *Endosomal Sorting Complexes Required for Transport Signal Transduction src Homology Domains.
STAM2 protein, human  0   *Adaptor Proteins, Signal Transducing *Endosomal Sorting Complexes Required for Transport. Trends Biochem Sci. 2007 Dec;32(12):561-73
Stam2 protein, mouse  0   *Phosphoproteins *Adaptor Proteins, Signal Transducing *Endosomal Sorting Complexes Required for Transport Signal Transduction src Homology Domains.
Vps36 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Endosomal Sorting Complexes Required for Transport. Nature 2004 Sep 9;431(7005):221-5; Trends Biochem Sci. 2007 Dec;32(12):561-73
Vps25 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Endosomal Sorting Complexes Required for Transport. Nature 2004 Sep 9;431(7005):221-5; Trends Biochem Sci. 2007 Dec;32(12):561-73
VPS4A protein, human  EC 3.6.1.-   *Vacuolar Proton-Translocating ATPases *Endosomal Sorting Complexes Required for Transport. Trends Biochem Sci. 2007 Dec;32(12):561-73
VPS4B protein, human  0   *Adenosine Triphosphatases *Endosomal Sorting Complexes Required for Transport.
VTA1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Endosomal Sorting Complexes Required for Transport. J Cell Sci 2003 Oct 1;116(Pt 19);3957-70; Trends Biochem Sci. 2007 Dec;32(12):561-73
STAMBP protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase *Endosomal Sorting Complexes Required for Transport src Homology Domains. Trends Biochem Sci. 2007 Dec;32(12):561-73
CHMP4A protein, human  0   *Endosomal Sorting Complexes Required for Transport. Biochem J 2004 Feb 1;377(Pt 3):693-700; Trends Biochem Sci. 2007 Dec;32(12):561-73
CHMP6 protein, human  0   *Endosomal Sorting Complexes Required for Transport. Biochem J 2004 Feb 1;377(Pt 3):693-700; Trends Biochem Sci. 2007 Dec;32(12):561-73
Bro1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Endosomal Sorting Complexes Required for Transport. J Biol Chem 2003 Dec 12;278(50):50732-43; Trends Biochem Sci. 2007 Dec;32(12):561-73
CHMP4B protein, human  0   *Endosomal Sorting Complexes Required for Transport. J Biol Chem 2003 Oct 3;278(40):39104-13; Trends Biochem Sci. 2007 Dec;32(12):561-73
Chmp3 protein, mouse  0   *Endosomal Sorting Complexes Required for Transport. J Biol Chem 2003 Oct 3;278(40):38786-95
VPS28 protein, human  0   *Endosomal Sorting Complexes Required for Transport. J Virol. 2003 Aug;77(15):8440-7; Trends Biochem Sci. 2007 Dec;32(12):561-73
RSP5 protein, S cerevisiae  EC 6.3.2.19   *Saccharomyces cerevisiae Proteins *Ubiquitin-Protein Ligase Complexes *Endosomal Sorting Complexes Required for Transport. Trends Biochem Sci. 2007 Dec;32(12):561-73
Hse1 protein, S cerevisiae  0   *Receptors, Cytoplasmic and Nuclear *Saccharomyces cerevisiae Proteins *Endosomal Sorting Complexes Required for Transport. Nat Cell Biol 2002 Jul;4(7):534-9
CHMP1A protein, human  0   *Endosomal Sorting Complexes Required for Transport. J Cell Sci 2001 Jul;114(Pt 13):2383-93; Trends Biochem Sci. 2007 Dec;32(12):561-73
Stambp protein, mouse  EC 3.4.99.-   *Endopeptidases *Ubiquitin Thiolesterase *Endosomal Sorting Complexes Required for Transport src Homology Domains. Mol Cell Biol 2001 Dec;21(24):8626-37
VPS60 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Endosomal Sorting Complexes Required for Transport. Mol Biol Cell 2001 May;12(3):711-23; Trends Biochem Sci. 2007 Dec;32(12):561-73
EAP45 protein, rat  0   *DNA-Binding Proteins *Transcription Factors *Endosomal Sorting Complexes Required for Transport. J Biol Chem 2001 May 11;276(19):16528-33
EAP20 protein, rat  0   *DNA-Binding Proteins *Transcription Factors *Endosomal Sorting Complexes Required for Transport. BMC Evol Biol. 2006 Aug 4;6:59; J Biol Chem 2001 May 11;276(19):16528-33
STP22 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Endosomal Sorting Complexes Required for Transport. Traffic 2000 Mar;1(3):248-58; Trends Biochem Sci. 2007 Dec;32(12):561-73
VPS27 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Endosomal Sorting Complexes Required for Transport. Cell 1999 May 28;97(5):657-66; Trends Biochem Sci. 2007 Dec;32(12):561-73
PDCD6IP protein, human  0   *Calcium-Binding Proteins *Cell Cycle Proteins *Endosomal Sorting Complexes Required for Transport. J Biol Chem 1999 Jan 15;274(3):1533-40; Trends Biochem Sci. 2007 Dec;32(12):561-73
Hgs protein, rat  0   *Adenosine Triphosphatases *Phosphoproteins *Endosomal Sorting Complexes Required for Transport Nerve Tissue Proteins Zinc Fingers Leucine Zippers. J Neurochem 1998 Nov;71(5):1827-36; Nature 1997 Feb 27;385(6619):826-9
SRN2 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Endosomal Sorting Complexes Required for Transport. Mol Gen Genet 1998 Sep;259(4):404-13; Trends Biochem Sci. 2007 Dec;32(12):561-73
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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