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Cholenes

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Definition: Unsaturated derivatives of cholane with methyl groups at C-10 and C-13 and a branched five-carbon chain at C-17. They must have at least one double bond in the ring system.  do not confuse with CHOLANES or CHOLINE; includes choladienes, cholatrienes   
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
epoxyscillirosidin  0   *Cholenes Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Int J Biochem Cell Biol 1997 Aug-Sep;29(8-9):1103-12
3-((2-O-(6-deoxy-4-O-(4-hydroxybenzoyl)mannopyranosyl)glucopyranosyl)oxy)-16,23-epoxy-23-hydroxy-22-(2-methyl-1-propenyl)-24-norchol-5-en-18-al  153005-22-2   *Cholenes *Glycosides Ornithogalum. Life Sci 1996;58(9):789-98
22-hydroximino-23,24-bisnor-4-cholen-3-one  0   *Cholenes. Prostate 1995 Mar;26(3):140-50
22-phenoxazonoxy-5-cholene-3 beta-ol  135212-24-7   *Cholenes *Oxazines. J Steroid Biochem Mol Biol 1992 Nov;43(6):479-87
3-hydroxy-15-keto-chol-8(14)-en-24-oic acid  136320-56-4   *Cholenes. J Lipid Res 1992 Apr;33(4):579-98
3-hydroxy-24-dimethylaminochol-8(14)-en-15-one  136320-61-1   *Cholenes Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Chem Phys Lipids 1991 Nov ;60(1):61-9
3-hydroxy-19-nor-1,3,5(10)-cholatrien-24-oic acid  100772-18-7   *Cholenes Norsteroids. J Lipid Res 1988;29(6):809
24-(12-hydroxy-3-oxo-4-cholenoyl-5'phospho)-3'phosphoadenosine  115288-28-3   *Cholenes Adenosine Diphosphate/*analogs & derivatives Bile Acids and Salts. J Biol Chem 1987;262(10):4701
3,7,12-trihydroxy-5-cholenoic acid  108906-88-3   *Cholenes Bile Acids and Salts. J Clin Invest 1987;79(4):1031
24-(isopropylseleno)chol-5-en-3-ol  86508-37-4   *Cholenes *Organoselenium Compounds. J Med Chem 1983;26(10):1538
tauro-3 beta-hydroxy-5-cholenoate  17238-48-1   *Cholenes Bile Acids and Salts. Gastroenterology 1983;85(3):674
24-(isopropyltelluro)chol-5-en-3 beta-ol  72249-76-4 (3 beta)-24-((1-methylethyl)telluro)chol-5-en-3-ol  *Cholenes *Tellurium. J Nucl Med 1980;21(5):454
N-(2-naphthyl)-23,24-dinor-5-cholen-22-amin-3 beta-ol  67675-20-1 Pregn-5-en-3-ol, 20-methyl-21-(2-naphthalenylamino)-, (3beta,20S)  *Cholenes. Biochemistry 17(13):2689;1978
3-hydroxychol-8-en-24-oic acid  0   *Cholenes. Steroids 30(3):393;1977
3 beta-methoxy-dinor-5-cholen-22-ol  0   *Cholenes. Acta Microbiol 22(4):447;1975
3 beta-methoxy-dinor-5,17(20)choladien-22-oic acid methyl ester  0   *Cholenes. Acta Microbiol 22(4):447;1975
3-hydroxychol-11-en-24-oic acid  0   *Cholenes. J Chem Soc Perkin I 14(0):1597;1974; J Steroid Biochem 8(1):69;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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