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Bisbenzimidazole
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Definition
: A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.
Pharmacological Action
Filaricides
;
Fluorescent Dyes
Other names
Bisbenzimide; NSC322921; NSC 322921; Hoe33258; Hoe 33258; Pibenzimol; NSC-
322921; Hoechst 33258; Hoe-
33258; Bisbenzimidazole Trihydrochloride; 4-
(5-
(4-
Methyl-
1-
piperazinyl)(2,5'-
bi-
1H-
benzimida
Substance
CAS Registry & name
Categories
Source
Drugs
*
Hoe 43254
0
*Pyrimidines
Bisbenzimidazole/*analogs & derivatives.
Nucleic Acids Res 1998 Apr 1;26(7):1660-7
H.A.-
yellow
0
*Polyethylene Glycols
Bisbenzimidazole/*analogs & derivatives.
Nucleic Acids Res 1997 Dec 15;25(24):5125-6
4-
(5-
(5-
(4-
methyl-
1-
piperazinyl)-
1H-
imidazo(4,5-
b)pyridin-
2-
yl)-
2-
benzoxazolyl)phenol
126898-32-6
Bisbenzimidazole/*analogs & derivatives
Ligands.
J Biomol Struct Dyn 1992 Dec;10(3):565-75
2-
(4-
methoxyphenyl)-
5-
((4-
methylpiperazin-
1-
yl)-
3H-
imidazo(4,5-
b)pyridin-
2-
yl)-
3H-
imidazo(4,5-
b)pyridine
142764-75-8
Bisbenzimidazole/*analogs & derivatives
Ligands
DNA Topoisomerases, Type II/antagonists & inhibitors.
Chem Res Toxicol 1992 Sep-Oct;5(5):597-607
2-
(2-
(3-
iodo-
4-
hydroxyphenyl)-
6-
benzimidazolyl)-
6-
(1-
methyl-
4-
piperazyl)benzimidazole
106050-84-4
Bisbenzimidazole/*analogs & derivatives.
Int J Radiat Biol 1990;57(5):939
compound E (Friedheim)
0
*Arsenicals
Bisbenzimidazole/*analogs & derivatives.
J Helminthol 50(1):49;1976; Tropenmed Parasitol 28:447;1977
V5851
62570-11-0 3,3'-
(((4-
((4,6-
diamino-
1,3,5-
triazin-
2-
yl)amino)phenyl)arsinidene)bis(thio))bis-
D-
valine, mixt. with 4-
(5-
(4-
methyl-
1-
piperazinyl)(2,5-
bi-
1H-
benzimidazol)-
2'-
yl)phenol trihydrochloride
*Arsenicals
*Bisbenzimidazole
Drug Combinations.
J Helminthol 50:243;1976