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Bisbenzimidazole

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Definition: A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.     
Pharmacological Action Filaricides; Fluorescent Dyes 		Other names Bisbenzimide; NSC322921; NSC 322921; Hoe33258; Hoe 33258; Pibenzimol; NSC-322921; Hoechst 33258; Hoe-33258; Bisbenzimidazole Trihydrochloride; 4-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimida
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Hoe 43254  0   *Pyrimidines Bisbenzimidazole/*analogs & derivatives. Nucleic Acids Res 1998 Apr 1;26(7):1660-7
H.A.-yellow  0   *Polyethylene Glycols Bisbenzimidazole/*analogs & derivatives. Nucleic Acids Res 1997 Dec 15;25(24):5125-6
4-(5-(5-(4-methyl-1-piperazinyl)-1H-imidazo(4,5-b)pyridin-2-yl)-2-benzoxazolyl)phenol  126898-32-6   Bisbenzimidazole/*analogs & derivatives Ligands. J Biomol Struct Dyn 1992 Dec;10(3):565-75
2-(4-methoxyphenyl)-5-((4-methylpiperazin-1-yl)-3H-imidazo(4,5-b)pyridin-2-yl)-3H-imidazo(4,5-b)pyridine  142764-75-8   Bisbenzimidazole/*analogs & derivatives Ligands DNA Topoisomerases, Type II/antagonists & inhibitors. Chem Res Toxicol 1992 Sep-Oct;5(5):597-607
2-(2-(3-iodo-4-hydroxyphenyl)-6-benzimidazolyl)-6-(1-methyl-4-piperazyl)benzimidazole  106050-84-4   Bisbenzimidazole/*analogs & derivatives. Int J Radiat Biol 1990;57(5):939
compound E (Friedheim)  0   *Arsenicals Bisbenzimidazole/*analogs & derivatives. J Helminthol 50(1):49;1976; Tropenmed Parasitol 28:447;1977
V5851  62570-11-0 3,3'-(((4-((4,6-diamino-1,3,5-triazin-2-yl)amino)phenyl)arsinidene)bis(thio))bis-D-valine, mixt. with 4-(5-(4-methyl-1-piperazinyl)(2,5-bi-1H-benzimidazol)-2'-yl)phenol trihydrochloride  *Arsenicals *Bisbenzimidazole Drug Combinations. J Helminthol 50:243;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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