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Cycloleucine

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Definition: An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.      Other names 1-Aminocyclopentanecarboxylic Acid; Acid, Aminocyclopentanecarboxylic; Acid, 1-Aminocyclopentanecarboxylic; 1026, NSC; 1 Aminocyclopentanecarboxylic Acid; NSC 1026; Aminocyclopentanecarboxylic Acid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-amino-2-fluorocyclopentyl-1-carboxylic acid  0   Cycloleucine/*analogs & derivatives Fluorine Radioisotopes. J Med Chem 2010 Sep 23;53(18):6603-7
2-amino-2,3-dihydro-1H-cyclopenta(b)anthracene-2-carboxylic acid  0   *Anthracenes Cycloleucine/*analogs & derivatives. Biopolymers 2007;88(6):797-806
PLD118  0   Cycloleucine/*analogs & derivatives. Drug Discov Today 2002 Mar 15;7(6):332-3
2-amino-4-methylenecyclopentane-1-carboxylic acid  0   Cycloleucine/*analogs & derivatives. Antimicrob Agents Chemother 1998 Jul;42(7):1581-6
Z 4212  125483-43-4 Cyclopentanecarboxylic acid, 1-((3-amino-2-hydroxy-4-(4-(methylsulfonyl)phenyl)-1-oxobutyl)amino)-, (S-(R*,S*))  Cycloleucine/*analogs & derivatives. Neuropeptides 1993 Sep;25(3):175-82
cispentacin  3814-46-8   Cycloleucine/analogs & derivatives. Nature 1997 May 22;387(6631):381-4
1-amino-1,3-dicarboxycyclopentane  111900-32-4   Cycloleucine/*analogs & derivatives Neurotoxins Stereoisomerism Receptors, Metabotropic Glutamate/agonists.
Pharma Action Neuroprotective Agents 		J Comp Neurol 1982;211(2):105
1-amino-2-methylcyclopentanecarboxylic acid  3198-65-0 Cyclopentanecarboxylic acid, 1-amino-2-methyl  Cycloleucine/*analogs & derivatives. Cancer Res 38(8):2271;1978
1-amino-3-methylcyclopentanecarboxylic acid  17199-38-1 Cyclopentanecarboxylic acid, 1-amino-3-methyl  Cycloleucine/*analogs & derivatives. Cancer Res 38(8):2271;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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