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Isatin

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Definition: An indole-dione that is obtained by oxidation of indigo blue. It is a MONOAMINE OXIDASE INHIBITOR and high levels have been found in urine of PARKINSONISM patients.  do not confuse with isatan    Other names 2,3 Dioxoindoline; 2,3-Dioxoindoline
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
VU 01119498  0   Isatin/*analogs & derivatives Receptor, Muscarinic M5/agonists. J Med Chem 2009 Jun 11;52(11):3445-8
convolutamydine A  0   Isatin/*analogs & derivatives Alkaloids. Chemistry. 2008;14(27):8079-81
5,7-dibromo-N-(4-methylbenzyl)isatin  0   Isatin/*analogs & derivatives. J Med Chem 2007 Oct 18;50(21):5109-17
isatisine A  0   *Indole Alkaloids Isatin/*analogs & derivatives. Org Lett 2007 Oct 11;9(21):4127-9
7-trifluoromethylisatin  0   Isatin/*analogs & derivatives. Acta Crystallogr C 2006 Jun;62(Pt 6):o321-3
5-iodoisatin  0   Isatin/*analogs & derivatives. Acta Crystallogr C 2006 Jun;62(Pt 6):o321-3
((2-hydroxy-1-naphthaldehyde)-3-isatin)-bishydrazone  0   *Hydrazones *Naphthalenes Isatin/*analogs & derivatives. J Enzyme Inhib Med Chem. 2007 Feb;22(1):65-70
1-(4-(2-fluoroethoxy)benzyl)-5-(1-(2-methoxymethylpyrrolidinyl)sulfonyl)isatin  0   *Pyrrolidines Isatin/*analogs & derivatives Caspase 3/antagonists & inhibitors. J Med Chem 2006 Nov 16;49(23):6704-15
1-methylisatin 3-semicarbazone  0   *Semicarbazones Isatin/*analogs & derivatives. Acta Crystallogr C 2005 Oct;61(Pt 10):o589-92
isatin 3-semicarbazone  0   *Semicarbazones Isatin/*analogs & derivatives. Acta Crystallogr C 2005 Oct;61(Pt 10):o589-92
convolutamydine B  0   Isatin/*analogs & derivatives. Org Lett 2006 Feb 16;8(4):677-9
convolutamydine E  0   Isatin/*analogs & derivatives. Org Lett 2006 Feb 16;8(4):677-9
isatin 3-picolinoyl hydrazone  0   *Hydrazones Isatin/*analogs & derivatives. J Inorg Biochem. 2004 Feb;98(2):313-21
N-methylisatin 3-picolinoyl hydrazone  0   *Hydrazones Isatin/*analogs & derivatives. J Inorg Biochem. 2004 Feb;98(2):313-21
5-(1-(2-methoxymethylpyrrolidinyl)sulfonyl)isatin  0   *Pyrrolidines Isatin/*analogs & derivatives. Eur J Pharmacol 2002 Dec 5;456(1-3):59-68
5-hydroxyisatin  0   Isatin/*analogs & derivatives. Vopr Med Khim 2002 Mar-Apr;48(2):201-3
5-aminoisatin  0   Isatin/*analogs & derivatives Biosensing Techniques. Vopr Med Khim 2002 Jan-Feb;48(1):73-83
isatin-3-oxime  0   Isatin/*analogs & derivatives. Nat Prod Lett 2001;15(2):119-24
isatin-3-oxime-glucoside  0   *Glucosides Isatin/*analogs & derivatives. Nat Prod Lett 2001;15(2):119-24
1-acetylisatin  574-17-4   Isatin/*analogs & derivatives. Org Lett 2000 Aug 24;2(17):2583-6
propargylic sulfone  0   *Alkynes Isatin/*analogs & derivatives. Bioorg Med Chem Lett 1998 Jan 20;8(2):169-74
1-morpholinomethyl-5-methylisatin  0   Isatin/*analogs & derivatives. Rev Med Chir Soc Med Nat Iasi 1996 Jan-Jun;100(1-2):167-71
5-methylisatin  608-05-9   Isatin/*analogs & derivatives. Rev Med Chir Soc Med Nat Iasi 1996 Jan-Jun;100(1-2):167-71
isatin-5-sulfonic acid  80789-74-8   Isatin/*analogs & derivatives. Environ Mol Mutagen 1994;23(1):51-63
N-allylisatin-beta-4',4'-diallylthiosemicarbazone  152128-80-8   *Thiosemicarbazones Isatin/*analogs & derivatives. Antimicrob Agents Chemother 1993 Nov;37(11):2483-5
3-(1-hexynyl)-3-hydroxy-2-indolinone  149916-72-3   *Alkynes Isatin/*analogs & derivatives. J Pharm Sci 1993 Jun;82(6):605-9
1-methyl-3-(1-hexynyl)-3-hydroxy-2-indolinone  149916-73-4   *Alkynes Isatin/*analogs & derivatives. J Pharm Sci 1993 Jun;82(6):605
3-(1-hexynyl)-3-hydroxy-5-nitro-2-indolinone  149916-74-5   *Alkynes Isatin/*analogs & derivatives. J Pharm Sci 1993 Jun;82(6):605-9
6-(3'-methylbuten-2'-yl)isatin  101023-73-8   Isatin/*analogs & derivatives. J Antibiot (Tokyo) 1986;39(1):162
1-ethylisatin-S-n-butylisothiosemicarbazone  39497-42-2   Isatin/*analogs & derivatives. Acta Virol (Praha) 1985;29(3):216
5-butylisatin  18331-71-0   Isatin/*analogs & derivatives. Vopr Med Khim 1984;30(5):56
5-bromoisatin  87-48-9   Isatin/*analogs & derivatives. Vopr Med Khim 1984;30(5):56
tribulin  84788-92-1   *Isatin Biological Markers.
Pharma Action Monoamine Oxidase Inhibitors 		Subst Alcohol Actions Misuse 1983;4(2-3):89; Yakugaku Zasshi. 2000 Apr;120(4):352-62
isatin isothiosemicarbazone  0   Isatin/*analogs & derivatives. Acta Virol 23(1):45;1979
isatogen  5814-98-2 3H-Indol-3-one, 1-oxide  Isatin/*analogs & derivatives. Br J Pharmacol 63:309;1978
2,2'-pyridylisatogen  2922-11-4   Isatin/*analogs & derivatives. Br J Pharmacol 1979;67(3):480P; Br J Pharmacol 63:125;1978; Br J Pharmacol 63:659;1978; J Pharm Pharmacol 31(3):189;1979; Life Sci 24(14):1299;1979
N-4-chlorobenzoylisatinic acid  54778-24-4 Benzeneacetic acid, 2-((4-chlorobenzoyl)amino)-alpha-oxo  Isatin/*analogs & derivatives. Boll Chim Pharm 116(8):493;1977
N-benzoylisatinic acid  54778-23-3 Benzeneacetic acid, 2-(benzoylamino)-alpha-oxo  Isatin/*analogs & derivatives. Boll Chim Pharm 116(8):493;1977
isatin beta-thiosemicarbazone  487-16-1 2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazinecarbothioamide  Isatin/*analogs & derivatives. Acta Microb Polon 27(2):111;1978; J Gen Virol 40(3):695;1978; Veterinariia 2:45;1977; Virology 74(2):426;1976
2,2'-pyridylisatogen tosylate  56583-49-4   Isatin/*analogs & derivatives Receptors, Purinergic P2/antagonists & inhibitors. Br J Pharmacol 50(3):458P;1974; Br J Pharmacol 53(4):575;1975; Br J Pharmacol 63(2):378P;1978; Br J Pharmacol 63(2):408p;1978; J Pharm Pharmacol 29(9):542;1977; J Pharm Pharmacol 30(5):335;1978
2-phenylisatogen  1969-74-0   Isatin/*analogs & derivatives. Biochem Biophys Res Commun 58(1):337;1974; Br J Pharmacol 1979;67(3):480P; FEBS Lett 14:306;1971
N-ethylisatin-beta-thiosemicarbazone  607-05-6 1-ethylindole-2,3-dione-3-(thiosemicarbazone)  Isatin/*analogs & derivatives.
laxagetten 4,4'-diacetoxydiphenylpyridylemethane  18869-73-3   *Pyridines *Succinates Drug Combinations Isatin/*analogs & derivatives.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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