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Caspase 3

More information in Books or onNLM PubMed
Definition: A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.      Other names Procaspase 3; Pro Caspase 3; Procaspase-3; Pro-Caspase-3; Caspase-3; Apopain; CASP3
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
benzyloxycarbonyl-tert-leucyl-aspartic acid  0   *Dipeptides Caspase 3/antagonists & inhibitors. Biochem Biophys Res Commun 2008 Dec 19;377(3):757-62
4-(ethoxycarbonylmethoxy)-1-hydroxy-2-naphthoic acid  0   *Naphthols Caspase 3/antagonists & inhibitors. Bioorg Med Chem 2008 May 1;16(9):4854-9
1-(4-(2-fluoroethoxy)benzyl)-5-(1-(2-methoxymethylpyrrolidinyl)sulfonyl)isatin  0   *Pyrrolidines Isatin/*analogs & derivatives Caspase 3/antagonists & inhibitors. J Med Chem 2006 Nov 16;49(23):6704-15
Casp3 protein, rat  EC 3.4.22.-   *Caspase 3.
Casp3 protein, mouse  EC 3.4.22.-   *Caspase 3.
CASP3 protein, human  EC 3.4.22.-   *Caspase 3.
DEVDase  EC 3.4.99.-   *Peptide Hydrolases Caspase 3. Oncogene 1997 Sep 25;15(13):1573-81

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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