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ψ
ψ
ψ
1-Naphthylamine
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Definition
: A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.
a carcinogen; D25-26 qualif
Pharmacological Action
Carcinogens
Examples
Sertraline
Other names
alpha-
Naphthylamine; 1-
Aminonaphthalene; alpha Naphthylamine; 8 Aminonaphthalene; 1 Naphthylamine; 1 Aminonaphthalene; Naphthalidine; 8-
Aminonaphthalene
Substance
CAS Registry & name
Categories
Source
Drugs
*
N,N-
bis((E)-
2-
thienylmethylidene)-
1,8-
naphthalenediamine
0
1-Naphthylamine/*analogs & derivatives.
J Photochem Photobiol B. 2011 Sep 2;104(3):449-56
N,N-
dimethylaminonapthyl-
(acrylo)-
nitrile
0
*Nitriles
1-Naphthylamine/*analogs & derivatives.
Spectrochim Acta A Mol Biomol Spectrosc 2011 May;78(5):1525-34
3-
(4,5-
bis(dimethylamino)napthalen-
1-
yl)furan-
2,5-
dione
0
*Maleic Anhydrides
1-Naphthylamine/*analogs & derivatives.
J Org Chem. 2010 Oct 15;75(20):6977-9
N,N-
dimethylamino naphthyl acrylic acid ethyl ester
0
*Acrylates
1-Naphthylamine/*analogs & derivatives.
Photochem Photobiol Sci 2009 Jan;8(1):101-10
poly(1-
naphthylamine)
0
*Polymers
1-Naphthylamine/*analogs & derivatives.
J Biomater Sci Polym Ed 2008;19(11):1535-46
1-
(2-
((1-
amino-
1,2,3,4-
tetrahydronaphthalen-
2-
yl)carbonylamino)-
3-
(4-
chlorophenyl)propanoyl)-
N-
(tert-
butyl)-
4-
cyclohexylpiperidine-
4-
carboxamide
0
*Piperidines
1-Naphthylamine/*analogs & derivatives
Receptor, Melanocortin, Type 4/agonists.
Xenobiotica 2008 Nov;38(11):1437-51
1,5-
bis(4,6-
dichloro-
1,3,5-
triazinylamino)naphthalene
0
*Triazines
1-Naphthylamine/*analogs & derivatives.
Luminescence 2007 Nov-Dec;22(6):581-7
(R)-
N-
(benzimidazol-
2-
yl)-
1,2,3,4-
tetrahydro-
1-
naphthylamine
0
1-Naphthylamine/*analogs & derivatives.
Mol Pharmacol 2006 Nov;70(5):1771-82
N-
allyl-
4-
(4'-
methyl-
piperazinyl)-
1,8-
naphthalimide
0
*Piperazines
1-Naphthylamine/*analogs & derivatives.
Analyst 2005 Nov;130(11):1551-6
8-
(3-
(4-
cyclohexylpiperazin-
1-
yl)propyl)-
4-
methoxy-
5,6,7,8-
tetrahydronaphthalen-
1-
ylamine
0
1-Naphthylamine/*analogs & derivatives
Ligands.
J Med Chem 2006 Jul 13;49(14):4153-8
N-
(o-
boronic acid)benzyl-
1-
naphthylamine
0
*Boronic Acids
1-Naphthylamine/*analogs & derivatives.
Luminescence 2005 Jul-Oct;20(4-5):331-3
N-
phenyl-
2-
naphthalenamine
0
1-Naphthylamine/*analogs & derivatives.
Zhongguo Zhong Yao Za Zhi 2005 Mar;30(5):347-50
N(6)-
(1-
naphthyl)adenosine diphosphate
0
Adenosine Diphosphate/*analogs & derivatives
1-Naphthylamine/*analogs & derivatives.
J Med Chem 2005 Aug 25;48(17):5408-11
4-
(2-
chloroethyl)-
3-
(5,6,7-
trimethoxyindolyl-
2-
carboxamido)-
1-
naphthylamine
0
1-Naphthylamine/*analogs & derivatives.
J Med Chem 2005 Jun 2;48(11):3903-18
4-
(dimethylamino)naphthalene-
1-
boronic acid
0
*Boronic Acids
1-Naphthylamine/*analogs & derivatives.
Org Lett 2003 Nov 27;5(24):4599-602
1-
naphthylphenylamine
0
*Aniline Compounds
1-Naphthylamine/*analogs & derivatives.
Appl Environ Microbiol 2002 Sep;68(9):4502-8
1,8-
bis(dimethylamino)naphthalene
0
1-Naphthylamine/*analogs & derivatives.
Spectrochim Acta A Mol Biomol Spectrosc 2000 Aug;56A(9):1801-12
8-
dimethylamino-
1-
dimethylammonionaphthalene
0
1-Naphthylamine/*analogs & derivatives.
Acta Crystallogr C 1999 Sep 15;55( Pt 9):1499-503
norsertraline
0
1-Naphthylamine/*analogs & derivatives.
Biomed Chromatogr 1996 Nov-Dec;10(6):351-4
3-
bromo-
4-
(hexylamino)-
N-
hexyl-
1,8-
naphthalimide
0
*Naphthalimides
1-Naphthylamine/*analogs & derivatives.
Antiviral Res 1994 Oct;25(2):133-46
4-
amino-
1,8-
naphthalimide
1742-95-6
*Quinolones
*Naphthalimides
1-Naphthylamine/*analogs & derivatives
Poly(ADP-ribose) Polymerases.
Biochem Biophys Res Commun 1994 Mar 30;199(3):1270-7
1,14-
bis-
(N-
hexyl-
3'-
bromo-
1,8'-
naphthalimide-
4'-
yl)-
1,4,11,14-
tetraazatetradecane-
5,10-
dione
149849-59-2
*Naphthalimides
1-Naphthylamine/*analogs & derivatives
HIV-1.
AIDS Res Hum Retroviruses 1993 Sep;9(9):891-6
FD & C Yellow 11
2478-20-8
1-Naphthylamine/*analogs & derivatives
Cosmetics.
Contact Dermatitis 1975;1(2):121
CGS 21595
121412-39-3 1,2-
Naphthalenediol, 4-
(cyclohexylmethylamino)-
, diacetate (ester)
1-Naphthylamine/*analogs & derivatives.
Vet Pathol 1992 Mar;29(2):145-51
1-
benzoyl-
2-
(naphth-
1-
ylamino)ethene
69807-62-1
1-Naphthylamine/*analogs & derivatives.
Agents Actions 1991;32(1-1):112
N-
(guanin-
8-
yl)-
1-
naphthylamine
80156-61-2
1-Naphthylamine/*analogs & derivatives.
Chem Pharm Bull (Tokyo) 1981;29(9):2730
1-
N,N-
bis(beta-
bromoethyl)amino-
3-
methylnaphthalene
70974-82-2
1-Naphthylamine/*analogs & derivatives.
Br J Cancer 1982;45(6):830
N,N-
dimethyl-
1-
naphthylamine
86-56-6
1-Naphthylamine/*analogs & derivatives.
Lab Delo 1982;(3):27
1,5-
naphthalenediamine
2243-62-1
1-Naphthylamine/*analogs & derivatives.
IARC Monogr Eval Carcinog Risk Chem Human 1982;27:127
1,4-
naphthylenediamine
2243-61-0 1,4-
Naphthalenediamine
1-Naphthylamine/*analogs & derivatives.
Rev Inst Med Trop Sao Paulo 20(4):219;1978
N-
hydroxy-
1-
naphthylamine
607-30-7 N-
hydroxy-
1-
naphthalenamine
1-Naphthylamine/*analogs & derivatives.
Cancer Res 38(11):3628;1978
N-
heptyl-
1,2,3,4-
tetrahydro-
6-
methoxy-
1-
naphthylamine methanesulfonate
67510-73-0 1-
Naphthalenamine, N-
heptyl-
1,2,3,4-
tetrahydro-
6-
methoxy-
, methanesulfonate
1-Naphthylamine/*analogs & derivatives.
J Pharm Sci 67(6):882;1978
N-
phenyl-
1-
naphthylamine
90-30-2
1-Naphthylamine/*analogs & derivatives.
Pharma Action
Carcinogens
;
Fluorescent Dyes
Biochim Biophys Acta 449:401;1976; Biochim Biophys Acta 497:707;1977; Biochim Biophys Acta 512(1):72;1978; Blood 46(5):751;1975; FEBS Lett 77(2):187;1977; Immunofluorescence Relat Stain Tech W3 IN181T 6th 1978 p.58; J Chromatogr 120(1):211;1976; Mol Aspects Membrane Transport 22:567;1978
N-
methyl-
N-
1-
naphthyl-
2-
fluoroacetamide
5903-13-9
1-Naphthylamine/*analogs & derivatives.
Exp Anim (Tokyo) 21(2):89;1972
lometraline
39951-65-0 1-
naphthalenamine, 8-
chloro-
1,2,3,4-
tetrahydro-
5-
methoxy-
N,N-
dimethyl
1-Naphthylamine/*analogs & derivatives.
Curr Ther Res 14(2):65;1972