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Purine-Nucleoside Phosphorylase
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Definition
: An enzyme that catalyzes the reaction between a purine nucleoside and orthophosphate to form a free purine plus ribose-5-phosphate. EC 2.4.2.1.
Other names
Inosine Phosphorylase; Riboside Phosphorylase, Nicotinamide; Purine Nucleoside Phosphorylase; Phosphorylases, Purine Nucleoside; Phosphorylase, Purine-
Nucleoside; Phosphorylase, Nicotinamide Riboside; Phosphorylase, Inosine; Nucleoside Phosphorylases, Purine; Purine Nucleoside Phosphorylases; Nicotinamide Riboside Phosphorylase
Substance
CAS Registry & name
Categories
Source
Drugs
*
MTAN2 protein, Arabidopsis
EC 2.4.2.28
*Purine-Nucleoside Phosphorylase
*Arabidopsis Proteins.
Biochem Biophys Res Commun 2009 Apr 17;381(4):619-24
MTAN1 protein, Arabidopsis
EC 2.4.2.28
*Purine-Nucleoside Phosphorylase
*Arabidopsis Proteins.
Biochem Biophys Res Commun 2009 Apr 17;381(4):619-24
4'-
deaza-
1'-
aza-
2'-
deoxy-
1'-
(9-
methylene)immucillin G
0
*Pyrrolidines
Adenosine/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Biochemistry 2008 Feb 26;47(8):2559-64
4'-
deaza-
1'-
aza-
2'-
deoxy-
1'-
(9-
methylene)-
immucillin A
0
*Pyrrolidines
Adenine/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Biochemistry 2007 Jan 23;46(3):659-68
immucillin A
0
*Pyrrolidines
Adenine/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Biochemistry 2007 Jan 23;46(3):659-68
MT-
immucillin H
0
*Pyrimidinones
*Pyrrolidines
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Curr Top Med Chem 2005;5(13):1237-58
DADMe-
immucillin H
0
*Pyrimidinones
*Pyrrolidines
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Curr Top Med Chem 2005;5(13):1237-58
2-
(4-
amino-
5H-
pyrrolo-
(3,2-
d)pyrimidin-
7-
yl)-
5-
methylsulfanylmethylpyrrolidin-
3,4-
diol
0
*Pyrrolidines
Adenosine/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
J Med Chem 2004 Mar 11;47(6):1322-4
1-
((8-
aza-
9-
deazahypoxanthin-
9-
yl)methyl)-
3-
hydroxy-
4-
hydroxymethylpyrrolidine
0
*Hypoxanthines
*Pyrrolidines
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
J Med Chem 2003 Nov 20;46(24):5271-6
1-
((9-
deazaguanin-
9-
yl)methyl)-
3-
hydroxy-
4-
hydroxymethylpyrrolidine
0
*Pyrrolidines
Guanine/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
J Med Chem 2003 Nov 20;46(24):5271-6
1-
((9-
deazahypoxanthin-
9-
yl)methyl)-
3-
hydroxy-
4-
hydroxymethylpyrrolidine
0
*Hypoxanthines
*Pyrrolidines
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
J Med Chem 2003 Nov 20;46(24):5271-6
1,1-
difluoro-
2-
(tetrahydro-
3-
furanyl)ethylphosphonic acid
0
*Phosphonic Acids
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Bioorg Med Chem Lett 1999 Oct 4;9(19):2833-6
immucillin H
0
*Purine Nucleosides
*Pyrimidinones
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Biochemistry 1998 Jun 16;37(24):8615-21
immucillin G
0
*Pyrimidinones
*Pyrroles
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Biochemistry 1998 Jun 16;37(24):8615-21
9-
(3,3-
dimethyl-
5-
phosphonopentyl)guanine
155270-69-2
Guanine/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
J Med Chem 1994 Apr 15;37(8):1109-14
3-
(2-
amino-
4-
oxo-
3H,5H-
pyrrolo(3,2-
d)pyrimidin-
7-
yl)-
3-
(3-
chlorophenyl)propanoic acid
139367-68-3
*Pyrimidines
*Pyrroles
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
J Med Chem 1993 Nov 26;36(24):3771-83
9-
benzyl-
9-
deazaguanine
151561-89-6
*Benzyl Compounds
Guanine/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
J Pharmacol Exp Ther 1993 Aug;266(2):707-14
9-
deaza-
9-
(3-
thienylmethyl)guanine
132138-76-2
Guanine/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Biochem Pharmacol 1992 Sep 1;44(5):996-9
8-
amino-
3-
benzylhypoxanthine
139460-96-1
*Hypoxanthines
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
J Med Chem 1992 Apr 17;35(8):1451-7
8-
amino-
2'-
nordeoxyguanosine
98695-80-8 6H-
Purin-
6-
one, 2,8-
diamino-
1,9-
dihydro-
9-
((2-
hydroxy-
1-
(hydroxymethyl)ethoxy)methyl)
Deoxyguanosine/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
J Pharmacol Exp Ther 1992;260(1):319
CI 972
115787-68-3 4H-
Pyrrolo(3,2-
d)pyrimidin-
4-
one, 2,6-
diamino-
1,5-
dihydro-
7-
(3-
thienylmethyl)-
, monohydrochloride
*Pyrimidines
*Thiophenes
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Biochem Biophys Res Commun 1991;178(3):1351
5-
amino-
1-
ribofuranosyl-
1,2,4-
triazole-
3-
carboxamidine
111379-66-9
*Ribonucleosides
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
J Med Chem 1988;31(2):330
8-
amino-
9-
(2-
thienylmethyl)guanine
104162-90-5 6H-
Purin-
6-
one, 2,8-
diamino-
1,9-
dihydro-
9-
(2-
thienylmethyl)
Guanine/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Agents Actions 1987;21(3-4):272
5'-
methylthio-
5'-
deoxy-
9-
deazaadenosine
106175-18-2
Tubercidin/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Biochem Pharmacol 1987;36(13):2063
5'-
chloro-
5'-
deoxy-
9-
deazaadenosine
67377-77-9
Tubercidin/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Biochem Pharmacol 1987;36(13):2063
2,5-
diaminothiazolo(4,5-
d)pyrimidin-
7-
(6H)-
one
22288-77-3
Guanine/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
J Med Chem 1986;29(9):1804
2,5-
diaminothiazolo(5,4-
d)pyrimidin-
7(6H)-
one
103322-70-9
Guanine/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
J Med Chem 1986;29(9):1804
5'-
deoxy-
5'-
iodo-
9-
deazainosine
102731-46-4
Inosine/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Cancer Res 1986;46(4 Pt 1):1774
8-
amino-
9-
benzylguanine
100890-94-6
Guanine/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Cancer Res 1986;46(2):519
8-
aminoguanine
28128-41-8 6H-
Purin-
6-
one, 2,8-
diamino-
1,7-
dihydro
Guanine/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Biochem Pharmacol 1982;31(2):163
8-
aminoguanosine
3868-32-4
Guanosine/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Pharma Action
Enzyme Inhibitors
;
Immunosuppressive Agents
Science 1981;214(4525):1137
xanthosine phosphorylase
EC 2.4.2.-
*Purine-Nucleoside Phosphorylase.
MGG 1980;179(2):331
ribavirin amidine
40372-00-7
Ribavirin/*analogs & derivatives
Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Mol Pharmacol 1980;18(2):287
5'-
methylthioadenosine phosphorylase
EC 2.4.2.28
*Purine-Nucleoside Phosphorylase.
Biochem Biophys Res Commun 83(1):27;1978; Biochem J 175(3):1043;1978; Biochim Biophys Acta 1979;588(3):294; Biochim Biophys Acta 1980;627(2):190; Biochim Biophys Acta 523(1):82;1978; Biochim Biophys Acta 570(1):65;1979; Boll Soc Ital Biol Sper 1978;54(23):2355; Boll Soc Ital Biol Sper 1978;54(23):2362; Boll Soc Ital Sper 54(21):2091;1978; Eur J Biochem 1979;101(2):317; FEBS Lett 104(2):266;1979; Int J Biochem 1979;10(11):901; Int J Biochem 9(1):35;1978
adenosine phosphorylase
EC 2.4.2.-
*Purine-Nucleoside Phosphorylase.
Anal Biochem 1979;98(2):273; Anal Biochem 86:519;1978; FEBS Lett 64(2):353;1976; Proc Natl Acad Sci USA 72(4):1401;1975