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Purine-Nucleoside Phosphorylase

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Definition: An enzyme that catalyzes the reaction between a purine nucleoside and orthophosphate to form a free purine plus ribose-5-phosphate. EC 2.4.2.1.      Other names Inosine Phosphorylase; Riboside Phosphorylase, Nicotinamide; Purine Nucleoside Phosphorylase; Phosphorylases, Purine Nucleoside; Phosphorylase, Purine-Nucleoside; Phosphorylase, Nicotinamide Riboside; Phosphorylase, Inosine; Nucleoside Phosphorylases, Purine; Purine Nucleoside Phosphorylases; Nicotinamide Riboside Phosphorylase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MTAN2 protein, Arabidopsis  EC 2.4.2.28   *Purine-Nucleoside Phosphorylase *Arabidopsis Proteins. Biochem Biophys Res Commun 2009 Apr 17;381(4):619-24
MTAN1 protein, Arabidopsis  EC 2.4.2.28   *Purine-Nucleoside Phosphorylase *Arabidopsis Proteins. Biochem Biophys Res Commun 2009 Apr 17;381(4):619-24
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)immucillin G  0   *Pyrrolidines Adenosine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Biochemistry 2008 Feb 26;47(8):2559-64
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin A  0   *Pyrrolidines Adenine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Biochemistry 2007 Jan 23;46(3):659-68
immucillin A  0   *Pyrrolidines Adenine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Biochemistry 2007 Jan 23;46(3):659-68
MT-immucillin H  0   *Pyrimidinones *Pyrrolidines Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Curr Top Med Chem 2005;5(13):1237-58
DADMe-immucillin H  0   *Pyrimidinones *Pyrrolidines Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Curr Top Med Chem 2005;5(13):1237-58
2-(4-amino-5H-pyrrolo-(3,2-d)pyrimidin-7-yl)-5-methylsulfanylmethylpyrrolidin-3,4-diol  0   *Pyrrolidines Adenosine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. J Med Chem 2004 Mar 11;47(6):1322-4
1-((8-aza-9-deazahypoxanthin-9-yl)methyl)-3-hydroxy-4-hydroxymethylpyrrolidine  0   *Hypoxanthines *Pyrrolidines Purine-Nucleoside Phosphorylase/antagonists & inhibitors. J Med Chem 2003 Nov 20;46(24):5271-6
1-((9-deazaguanin-9-yl)methyl)-3-hydroxy-4-hydroxymethylpyrrolidine  0   *Pyrrolidines Guanine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. J Med Chem 2003 Nov 20;46(24):5271-6
1-((9-deazahypoxanthin-9-yl)methyl)-3-hydroxy-4-hydroxymethylpyrrolidine  0   *Hypoxanthines *Pyrrolidines Purine-Nucleoside Phosphorylase/antagonists & inhibitors. J Med Chem 2003 Nov 20;46(24):5271-6
1,1-difluoro-2-(tetrahydro-3-furanyl)ethylphosphonic acid  0   *Phosphonic Acids Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Oct 4;9(19):2833-6
immucillin H  0   *Purine Nucleosides *Pyrimidinones Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Biochemistry 1998 Jun 16;37(24):8615-21
immucillin G  0   *Pyrimidinones *Pyrroles Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Biochemistry 1998 Jun 16;37(24):8615-21
9-(3,3-dimethyl-5-phosphonopentyl)guanine  155270-69-2   Guanine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. J Med Chem 1994 Apr 15;37(8):1109-14
3-(2-amino-4-oxo-3H,5H-pyrrolo(3,2-d)pyrimidin-7-yl)-3-(3-chlorophenyl)propanoic acid  139367-68-3   *Pyrimidines *Pyrroles Purine-Nucleoside Phosphorylase/antagonists & inhibitors. J Med Chem 1993 Nov 26;36(24):3771-83
9-benzyl-9-deazaguanine  151561-89-6   *Benzyl Compounds Guanine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. J Pharmacol Exp Ther 1993 Aug;266(2):707-14
9-deaza-9-(3-thienylmethyl)guanine  132138-76-2   Guanine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Biochem Pharmacol 1992 Sep 1;44(5):996-9
8-amino-3-benzylhypoxanthine  139460-96-1   *Hypoxanthines Purine-Nucleoside Phosphorylase/antagonists & inhibitors. J Med Chem 1992 Apr 17;35(8):1451-7
8-amino-2'-nordeoxyguanosine  98695-80-8 6H-Purin-6-one, 2,8-diamino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)  Deoxyguanosine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. J Pharmacol Exp Ther 1992;260(1):319
CI 972  115787-68-3 4H-Pyrrolo(3,2-d)pyrimidin-4-one, 2,6-diamino-1,5-dihydro-7-(3-thienylmethyl)-, monohydrochloride  *Pyrimidines *Thiophenes Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Biochem Biophys Res Commun 1991;178(3):1351
5-amino-1-ribofuranosyl-1,2,4-triazole-3-carboxamidine  111379-66-9   *Ribonucleosides Purine-Nucleoside Phosphorylase/antagonists & inhibitors. J Med Chem 1988;31(2):330
8-amino-9-(2-thienylmethyl)guanine  104162-90-5 6H-Purin-6-one, 2,8-diamino-1,9-dihydro-9-(2-thienylmethyl)  Guanine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Agents Actions 1987;21(3-4):272
5'-methylthio-5'-deoxy-9-deazaadenosine  106175-18-2   Tubercidin/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Biochem Pharmacol 1987;36(13):2063
5'-chloro-5'-deoxy-9-deazaadenosine  67377-77-9   Tubercidin/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Biochem Pharmacol 1987;36(13):2063
2,5-diaminothiazolo(4,5-d)pyrimidin-7-(6H)-one  22288-77-3   Guanine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. J Med Chem 1986;29(9):1804
2,5-diaminothiazolo(5,4-d)pyrimidin-7(6H)-one  103322-70-9   Guanine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. J Med Chem 1986;29(9):1804
5'-deoxy-5'-iodo-9-deazainosine  102731-46-4   Inosine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Cancer Res 1986;46(4 Pt 1):1774
8-amino-9-benzylguanine  100890-94-6   Guanine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Cancer Res 1986;46(2):519
8-aminoguanine  28128-41-8 6H-Purin-6-one, 2,8-diamino-1,7-dihydro  Guanine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Biochem Pharmacol 1982;31(2):163
8-aminoguanosine  3868-32-4   Guanosine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Immunosuppressive Agents 		Science 1981;214(4525):1137
xanthosine phosphorylase  EC 2.4.2.-   *Purine-Nucleoside Phosphorylase. MGG 1980;179(2):331
ribavirin amidine  40372-00-7   Ribavirin/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Mol Pharmacol 1980;18(2):287
5'-methylthioadenosine phosphorylase  EC 2.4.2.28   *Purine-Nucleoside Phosphorylase. Biochem Biophys Res Commun 83(1):27;1978; Biochem J 175(3):1043;1978; Biochim Biophys Acta 1979;588(3):294; Biochim Biophys Acta 1980;627(2):190; Biochim Biophys Acta 523(1):82;1978; Biochim Biophys Acta 570(1):65;1979; Boll Soc Ital Biol Sper 1978;54(23):2355; Boll Soc Ital Biol Sper 1978;54(23):2362; Boll Soc Ital Sper 54(21):2091;1978; Eur J Biochem 1979;101(2):317; FEBS Lett 104(2):266;1979; Int J Biochem 1979;10(11):901; Int J Biochem 9(1):35;1978
adenosine phosphorylase  EC 2.4.2.-   *Purine-Nucleoside Phosphorylase. Anal Biochem 1979;98(2):273; Anal Biochem 86:519;1978; FEBS Lett 64(2):353;1976; Proc Natl Acad Sci USA 72(4):1401;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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