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HIV Reverse Transcriptase

More information in Books or onNLM PubMed
Definition: A reverse transcriptase encoded by the POL GENE of HIV. It is a heterodimer of 66 kDa and 51 kDa subunits that are derived from a common precursor protein. The heterodimer also includes an RNAse H activity (RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS) that plays an essential role the viral replication process.      Other names Transcriptase, HIV Reverse; Reverse Transcriptase, Human Immunodeficiency Viru; Reverse Transcriptase, HIV
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
cordysobin protein, Cordyceps sobolifera  EC 3.4.-   *Fungal Proteins *Serine Proteases Reverse Transcriptase Inhibitors HIV Reverse Transcriptase. J Biosci Bioeng. 2012 Jan;113(1):42-7.
2-(difluoro-((4-ethylpyrimidinyl)thio)methyl)benzoxazole  0   *Benzoxazoles *Pyrimidines Reverse Transcriptase Inhibitors HIV Reverse Transcriptase. J Med Chem. 2011 Dec 8;54(23):7974-85.
3'-azido-2',3'-dideoxycytidine  0   *Azides Zalcitabine/*analogs & derivatives Reverse Transcriptase Inhibitors HIV Reverse Transcriptase. Antimicrob Agents Chemother. 2011 Aug;55(8):3758-64.
3'-azido-2',3'-dideoxyadenosine  0   *Azides Dideoxyadenosine/*analogs & derivatives Reverse Transcriptase Inhibitors HIV Reverse Transcriptase. Antimicrob Agents Chemother. 2011 Aug;55(8):3758-64.
methyl 2-(aminocarbonyl)-5-chloro-1H-indol-3-yl-(phenyl)phosphinate  0   *Indoles *Phosphinic Acids HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 2011 Jan 13;54(1):392-5
3'-deoxy-3'-fluoro-2-thiothymidine 5'-triphosphate  0   *Thymine Nucleotides *Dideoxynucleotides HIV Reverse Transcriptase. Antiviral Res 2010 Nov;88(2):176-81
3'-deoxy-3'-fluoro-4-thiothymidine 5'-triphosphate  0   *Thymine Nucleotides *Dideoxynucleotides HIV Reverse Transcriptase. Antiviral Res 2010 Nov;88(2):176-81
N-(4-(((4-chloro-2-(3-chloro-5-cyanobenzoyl)phenoxy)acetyl)amino)-3-methylphenyl)sulfonylpropanamide  0   *Benzophenones *Sulfonamides HIV Reverse Transcriptase/antagonists & inhibitors. Xenobiotica 2010 Jun;40(6):437-45
YM 228855  0   *Sulfonamides *Thiazoles HIV Reverse Transcriptase/antagonists & inhibitors. Antivir Chem Chemother 2008;19(3):133-41
YM 215389  0   *Sulfonamides *Thiazoles HIV Reverse Transcriptase/antagonists & inhibitors. Antivir Chem Chemother 2008;19(3):133-41
3-(5-((6-amino-1H-pyrazolo(3,4-b)pyridine-3-yl)methoxy)-2-chlorophenoxy)-5-chlorobenzonitrile  0   *Pyrazoles *Pyridines HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 2008 Oct 23;51(20):6503-11
4-(3-iodophenyl)-3-oxobutanenitrile  0   *Butanones *Nitriles HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 2007 May 17;50(10):2370-84
2'-deoxy-4'-C-ethynyl-2-fluoroadenosine  0   *Deoxyadenosines HIV Reverse Transcriptase/antagonists & inhibitors. Chem Rec 2006;6(3):133-43
6-(alpha-cyanobenzyl)-3,4-dihydro-2-isopropylthio-5-methylpyrimidin-4(3H)-one  0   *Pyrimidinones HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 2007 Apr 19;50(8):1778-86
2-benzoylmethylthio-6-(alpha-cyano-(1-naphthylmethyl))-3,4-dihydro-5-methylpyrimidin-4(3H)-one  0   *Pyrimidinones HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 2007 Apr 19;50(8):1778-86
5-methyl-1-(4-nitrophenyl)-2-oxo-2,5-dihydro-1H-pyrido(3,2-b)indole-3-carbonitrile  0   *Indoles *Nitriles *Pyridones HIV Reverse Transcriptase/antagonists & inhibitors. J Virol 2006 Dec;80(24):12283-92
reverse transcriptase, Human immunodeficiency virus 1  EC 2.7.7.-   *HIV Reverse Transcriptase.
limenin protein, Phaseolus limensis  0   *Defensins HIV Reverse Transcriptase/antagonists & inhibitors. J Pept Sci 2006 May;12(5):341-6
MIV 150  0   *Pyridines Urea/*analogs & derivatives HIV Reverse Transcriptase/antagonists & inhibitors.
R 221239  0   *Pyridones HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 2005 Dec 1;48(24):7582-91
R 165481  0   *Pyridones HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 2005 Dec 1;48(24):7582-91
R 157208  0   *Pyridones HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 2005 Dec 1;48(24):7582-91
6-(2,6-dichlorobenzyl)-2-(2-(4-methoxyphenyl)ethylthio)-5-methylpyrimdin-4(3H)-one  0   *Pyrimidinones HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 2005 Dec 15;48(25):8000-8
vulgarinin, Phaseolus vulgaris  0   *Plant Proteins HIV Reverse Transcriptase/antagonists & inhibitors. Int J Biochem Cell Biol 2005 Aug;37(8):1626-32
trichogin protein, Tricholoma giganteum  0   *Fungal Proteins HIV Reverse Transcriptase/antagonists & inhibitors. Peptides 2005 Apr;26(4):575-80
coccinin protein, Phaseolus coccineus  0   *Peptides HIV Reverse Transcriptase/antagonists & inhibitors. Peptides 2004 Dec;25(12):2063-8
2,2-dimethylthiopropionic acid S-(2-((4-(3-(6-(3,5-dimethylbenzyl)-5-ethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)propenyl)phenoxy)-(5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dihydrofuran-2-ylmethoxy)phosphoryloxy)ethyl) ester  0   Thymidine Monophosphate/*analogs & derivatives HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 2005 Feb 24;48(4):1211-20
2,2-dimethylthiopropionic acid S-(2-((4-(4-benzyl-3-ethoxymethyl-5-isopropyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbonyl)phenoxy)-(5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dihydrofuran-2-ylmethoxy)phosphoryloxy)ethyl) ester  0   Thymidine Monophosphate/*analogs & derivatives HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 2005 Feb 24;48(4):1211-20
manicol  0   *Benzocycloheptenes Ribonuclease H/antagonists & inhibitors HIV Reverse Transcriptase/antagonists & inhibitors. Nucleic Acids Res 2005;33(4):1249-56
beta-thujaplicinol  0   Tropolone/*analogs & derivatives Ribonuclease H/antagonists & inhibitors HIV Reverse Transcriptase/antagonists & inhibitors. Nucleic Acids Res 2005;33(4):1249-56
Rilpivirine  500287-72-9   *Nitriles *Pyrimidines HIV Reverse Transcriptase/antagonists & inhibitors. AIDS Treat News. 2004 Nov-Dec;(407-408):4-5EDURANT
4-hydroxy-7-((((5-hydroxy-6-((4-cinnamylphenyl)azo)-7-sulfo-2-naphthalenyl)amino)carbonyl)amino)-3-((4-cinnamylphenyl))azo-2-naphthalenesulfonic acid  0   *Cinnamates *Naphthalenesulfonates HIV Reverse Transcriptase/antagonists & inhibitors. J Biol Chem 2004 Sep 10;279(37):38424-32
3-(4-(2-methylimidazo(4,5-c)pyridin-1-yl)benzyl)-3H-benzothiazol-2-one  0   *Imidazoles *Benzothiazoles HIV Reverse Transcriptase/antagonists & inhibitors. Proc Natl Acad Sci U S A 2004 Jul 20;101(29):10548-53
gymnin protein, Gymnocladus chinensis  0   *Defensins HIV Reverse Transcriptase/antagonists & inhibitors. Peptides 2003 Jul;24(7):963-8
2-cyclopentylamino-6-(1-(2,6-difluorophenyl)ethyl)-3,4-dihydro-5-methylpyrimidin-4(3H)-one  0   *Pyrimidinones HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 2004 Feb 12;47(4):928-34
TMC120-R147681  0   *Pyrimidines HIV Reverse Transcriptase/antagonists & inhibitors. Antimicrob Agents Chemother. 2004 Jan;48(1):337-9
synadenol triphosphate  0   *Nucleosides HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 2003 Oct 23;46(22):4799-802
1-(2-chloro-6-fluorophenyl)-1H,3H-oxazolo(3,4-a)benzimidazole  0   *Benzimidazoles *Oxazoles HIV Reverse Transcriptase. Antivir Chem Chemother 2001 May;12(3):169-74
1-phenyl-1H,3H-oxazolo(3,4-a)benzimidazole  0   *Benzimidazoles *Oxazoles HIV Reverse Transcriptase/antagonists & inhibitors. Antivir Chem Chemother 2001 May;12(3):169-74
polyacetylenetriol  0   *Polymers *Polyacetylenes HIV Reverse Transcriptase/antagonists & inhibitors. Biochem J 2002 Mar 15;362(Pt 3):685-92
phasein B  EC 3.2.1.-   *Chitinase HIV Reverse Transcriptase/antagonists & inhibitors. Biochem Biophys Res Commun 2002 Jan 18;290(2):813-9
phasein A  EC 3.2.1.-   *Chitinase HIV Reverse Transcriptase/antagonists & inhibitors. Biochem Biophys Res Commun 2002 Jan 18;290(2):813-9
ginkbilobin protein, Ginkgo biloba  0   *Plant Proteins HIV Reverse Transcriptase/antagonists & inhibitors. Biochem Biophys Res Commun 2000 Dec 20;279(2):407-11
4-chlorophenylhydrazone mesoxalic acid  0   *Hydrazones *Malonates HIV Reverse Transcriptase/antagonists & inhibitors. Biochemistry. 2000 Nov 21;39(46):14279-91
sefavirenz  0   *Oxazines HIV Reverse Transcriptase. FEBS Lett 2000 Apr 14;471(2-3):1186-94
1,5-diphenyl-3-(2-hydroxyethyl)-4-ethylpyrazole  0   *Pyrazoles HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 2000 Mar 9;43(5):1034-40
PETT 2  0   *Pyridines Thiourea/*analogs & derivatives HIV Reverse Transcriptase/antagonists & inhibitors. J Biol Chem 2000 Feb 25;275(8):5633-9
PETT 1  0   *Pyridines Thiourea/*analogs & derivatives HIV Reverse Transcriptase/antagonists & inhibitors. J Biol Chem 2000 Feb 25;275(8):5633-9
1-(2-(diphenylmethoxy)ethyl)-2-methyl-5-nitroimidazole  0   *Nitroimidazoles HIV Reverse Transcriptase/antagonists & inhibitors. Bioorg Med Chem Lett 2000 Feb 7;10(3):253-6
N-(2-(6-fluoro-2-hydroxy-3-propionylphenyl)cyclopropyl)-N'-(2-(5-bromopyridyl))urea  0   *Aminopyridines Urea/*analogs & derivatives HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 1999 Oct 7;42(20):4150-60
BM 50.0934  0   *Indoles *Thiazoles HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 1999 Sep 23;42(19):3845-51
BM 21.1326  0   *Indoles *Thiazoles HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 1999 Sep 23;42(19):3845-51
HIV-1 reverse transcriptase (395-404)  0   *Peptide Fragments *HIV Reverse Transcriptase. J Biol Chem 1999 Aug 27;274(35):24941-6
2-chloro-5,11-dihydro-11--ethyl-5-methyl-8-phenylethyl-6H-dipyrido(3,2-b-2',3'-e)(1,4)diazepin-6-one  0   Nevirapine/*analogs & derivatives HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 1998 Jul 30;41(16):2972-84
2-chloro-5,11-dihydro-11-ethyl-5-methyl-8-(2-(pyridin-4-yl)ethyl)-6H-dipyrido(3,2-b-2',3'-e)(1,4)diazepin-6-one  0   Nevirapine/*analogs & derivatives HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 1998 Jul 30;41(16):2972-84
pyridobenzo(b,f)1,5-oxazocyn-6-one  0   *Oxazocines *Pyridines HIV Reverse Transcriptase/antagonists & inhibitors. Farmaco 1997 Dec;52(12):751-3
6-((3,5-dimethylphenyl)thio)-5-ethyl-1-(3-(2-furyl)prop-2-en-1-yl)uracil  0   Uracil/*analogs & derivatives HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 1997 Jun 6;40(12):1845-54
5-ethyl-6-(phenylthio)-1-(3-(2-thienyl)prop-2-en-1-yl)uracil  0   Uracil/*analogs & derivatives HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 1997 Jun 6;40(12):1845-54
5-ethyl-1-(3-(2-furyl)prop-2-en-1-yl)-6-(phenylthio)uracil  0   Uracil/*analogs & derivatives HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 1997 Jun 6;40(12):1845-54
N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldeyde hydrazone  68758-85-0   *Hydrazones *Naphthols HIV Reverse Transcriptase/antagonists & inhibitors. Biochemistry 1997 Mar 18;36(11):3179-85
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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