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Ribonuclease H

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Definition: A ribonuclease that specifically cleaves the RNA moiety of RNA:DNA hybrids. It has been isolated from a wide variety of prokaryotic and eukaryotic organisms as well as RETROVIRUSES.     
Examples Ribonuclease H, Human Immunodeficiency Virus 		Other names Ribonuclease H, Calf Thymus; Endoribonuclease H; RNase H; RNAase H
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NSC 727447  0   *Thiophenes Ribonuclease H/antagonists & inhibitors. ACS Chem Biol 2008 Oct 17;3(10):635-44
NSC 727448  0   *Furans *Thiophenes Ribonuclease H/antagonists & inhibitors. ACS Chem Biol 2008 Oct 17;3(10):635-44
manicol  0   *Benzocycloheptenes Ribonuclease H/antagonists & inhibitors HIV Reverse Transcriptase/antagonists & inhibitors. Nucleic Acids Res 2005;33(4):1249-56
beta-thujaplicinol  0   Tropolone/*analogs & derivatives Ribonuclease H/antagonists & inhibitors HIV Reverse Transcriptase/antagonists & inhibitors. Nucleic Acids Res 2005;33(4):1249-56
4-(5-(benzoylamino)thien-2-yl)-2,4-dioxobutanoic acid  0   *Butyric Acids *Thiophenes Ribonuclease H/antagonists & inhibitors. J Biol Chem 2003 Jan 31;278(5):2777-80
PD 126338  0   *Hydrazones *Carboxylic Acids Ribonuclease H/antagonists & inhibitors. Biochemistry 1999 Oct 5;38(40):13070-6
DNA polymerase, Thermus thermophilus  EC 2.7.7.-   *DNA-Directed DNA Polymerase Exodeoxyribonucleases Ribonuclease H. Biochemistry 1995 Apr 18;34(15):4994-5002
ribonuclease HII  EC 3.1.26.-   *Ribonuclease H Escherichia coli Proteins. J Bacteriol 1995 Jan;177(1):264-7
ribonuclease HI  EC 3.1.26.4   *Ribonuclease H Saccharomyces cerevisiae Proteins Escherichia coli Proteins. J Biol Chem 1993 Jan 5;268(1):88-92
illimaquinone  71678-03-0 2,5-Cyclohexadiene-1,4-dione, 3-((decahydro-1,2,4a-trimethyl-5-methylene-1-naphthalenyl)methyl)-2-hydroxy-5-methoxy-, (1R-(1alpha,2beta,4abeta,8aalpha))  *Quinones Ribonuclease H/antagonists & inhibitors. Antimicrob Agents Chemother 1990;34(10):2009
primase-reverse transcriptase complex  0   *Multienzyme Complexes *RNA-Directed DNA Polymerase *Ribonuclease H *DNA Primase. Eur J Biochem 1991;195(1):157

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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