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4-hydroxytamoxifen

under Tamoxifen
More information in Books or onNLM PubMed
More on Tamoxifen Definition: One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.      Other names ICI47699; ICI46474; ICI46,474; ICI 47699; ICI 46474; ICI 46,474; Citrate, Tamoxifen; Zitazonium; Tomaxithen; Tamoxifen Citrate; Soltamox; Savient brand of Tamoxifen Citrate; Novaldex; Nolvadex; ICI-47699; ICI-46474; ICI-46,474 Drugs: SOLTAMOXNOLVADEX; TAMOXIFEN CITRATE;
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-hydroxytamoxifen [ 4'-hydroxytamoxifen,4-OHT hydrotamoxifen,4-hydroxy-tamoxifen,4-hydroxytamoxifen, (E)-isomer,4-hydroxytamoxifen, (Z)-isomer,4-monohydroxytamoxifen,ICI 79280,para-hydroxytamoxifen,tamoxifen metabolite B ]
  an antiestrogen; RN given refers to cpd without isomeric designation 		68392-35-8 phenol, 4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-,  Tamoxifen/*analogs & derivatives Receptors, Estrogen/agonists
Pharma Action Estrogen Antagonists 		Adv Exp Med Biol 117:133;1979; Biochem Biophys Res Commun 1979;91(3):812; J Endocrinol 76(2):363;1978; J Endocrinol 78(1):71;1978; J Steroid Biochem 1979;11(1A):285

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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