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Receptors, Estrogen
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Definition
: Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.
coord IM with specific estrogen (IM); DF: RECEPT ESTROGEN
Examples
Estrogen Receptor alpha
;
Estrogen Receptor beta
;
Receptors, Estradiol
Other names
Estrogen Receptors; Nuclear Receptor, Estrogen; Receptors, Estrogen, Type II; Receptors, Estrogen, Type I; Receptor, Estrogen Nuclear; Estrogen Receptors Type II; Estrogen Receptors Type I; Estrogen Receptor Type II; Estrogen Receptor Type I; Estrogen Nuclear Receptor
Substance
CAS Registry & name
Categories
Source
Drugs
*
2-
(4-
hydroxyphenyl)-
3-
phenylpent-
2-
enoic acid (4-
(2-
dimethylaminoethoxy)phenyl)amide
0
*Acrylamides
Ligands
Receptors, Estrogen/antagonists & inhibitors.
Endocrinology 2010 Oct;151(10):4926-37
N-
(3-
(4,5-
dihydro-
1,3-
thiazol-
2-
yl)-
1,3-
thiazolidin-
2-
ylidene)-
5H-
dibenzo(a,d)(7)annulen-
5-
amine
0
*Thiazolidines
Receptors, Estrogen/antagonists & inhibitors.
Mol Cancer Ther 2009 Mar;8(3):672-81
estrogen receptor 2a, zebrafish
0
*Receptors, Estrogen
*Zebrafish Proteins.
Dev Dyn 2006 Nov;235(11):3071-9
m-
bis(hydroxyphenyl)carborane
0
*Boron Compounds
*Phenols
Receptors, Estrogen/agonists.
Bioorg Med Chem Lett 2006 Aug 1;16(15):3943-6
Esrrg protein, rat
0
*Receptors, Estrogen.
Gene 2004 Oct 13;340(2):275-82
dfna5 protein, zebrafish
0
*Receptors, Estrogen
*Zebrafish Proteins
Deafness.
Dfna5h protein, mouse
0
*Receptors, Estrogen
Deafness.
ESRRB protein, human
0
*Receptors, Estrogen.
ESRRG protein, human
0
*Receptors, Estrogen.
Esrrg protein, mouse
0
*Receptors, Estrogen.
estrogen receptor activator protein, rat
0
*Proteins
Receptors, Estrogen.
Safb protein, rat
0
*Receptors, Estrogen
*Nuclear Matrix-Associated Proteins
*Matrix Attachment Region Binding Proteins.
SAFB2 protein, human
0
*Receptors, Estrogen
*Nuclear Matrix-Associated Proteins
*Matrix Attachment Region Binding Proteins.
ERB 041
0
*Oxazoles
Receptors, Estrogen/agonists.
Endocrinology 2003 Oct;144(10):4241-9
estrogen receptor deltaE7
0
*Receptors, Estrogen.
Endocrinology. 2003 Jul;144(7):2967-76
ERR protein, Drosophila
0
*Receptors, Estrogen
*Drosophila Proteins.
Biochemistry 2003 Jun 3;42(21):6427-35
7-
thiophenylestradiol
0
Estradiol/*analogs & derivatives
Receptors, Estrogen/agonists.
Endocrinology 2002 Oct;143(10):3785-95
ER-
X protein, mouse
0
*Receptors, Estrogen.
J Neurosci 2002 Oct 1;22(19):8391-401
estrogen receptor gamma
0
*Receptors, Estrogen.
Endocr Regul 2000 Dec;34(4):203-18
13beta-
methyl 19-
nor-
steroid
0
*Steroids
Receptors, Estrogen.
Steroids 2000 Oct - Nov;65(10 -11):763-71
1,3,5-
tris(4-
hydroxyphenyl)-
4-
propyl-
1H-
pyrazole
0
*Phenols
*Pyrazoles
Receptors, Estrogen/agonists.
J Med Chem 2000 Dec 28;43(26):4934-47
NNC 45-
0095
0
*Indolizines
*Pyrroles
Receptors, Estrogen/agonists.
Bioorg Med Chem Lett 2000 Feb 21;10(4):399-402
TERP-
1
0
*Receptors, Estrogen.
Mol Endocrinol 1999 Feb;13(2):320-91
DFNA5 protein, human
0
*Receptors, Estrogen
Deafness.
Eur J Biochem 1998 Feb 15;252(1):169-77
GPER protein, human
0
*Receptors, Estrogen
*Receptors, G-Protein-Coupled.
Biochem Biophys Res Commun 1997 Nov 26;240(3):737-41; Genomics 1997 Nov 1;45(3):607-17
SAFB protein, human
0
*Receptors, Estrogen
*Nuclear Matrix-Associated Proteins
*Matrix Attachment Region Binding Proteins.
J Cell Biochem 1997 Nov 1;67(2):275-86
levormeloxifene
78994-23-7
*Pyrrolidines
Receptors, Estrogen/agonists.
J Clin Invest 1997 Aug 15;100(4):821-8
estrogen receptor-
related receptor beta
0
*Receptors, Estrogen.
Nature 1997 Aug 21;388(6644):778-82
estrogen binding site, type II
0
*Receptors, Estrogen.
Am J Respir Cell Mol Biol 1997 Jul;17(1):51-9
Esrrb protein, mouse
0
*Receptors, Estrogen.
Genomics 1998 Jun 15;50(3):382-4; J Biol Chem 1996 Apr 26;271(17):9879-82; J Biol Chem 1999 Aug 6;274(32):22618-26
ERRalpha estrogen-
related receptor
0
*Receptors, Estrogen.
J Biol Chem 1996 Mar 8;271(10):5795-804
nuclear receptor interacting protein 1
0
*Nuclear Proteins
*Adaptor Proteins, Signal Transducing
Receptors, Estrogen
Repressor Proteins.
EMBO J 1995 Aug 1;14(15):3741-51
3-
(4-
(1,2-
diphenylbut-
1-
enyl)phenyl)acrylic acid
155701-61-4
*Cinnamates
*Stilbenes
Receptors, Estrogen/antagonists & inhibitors.
J Med Chem 1994 May 27;37(11):1550-2
ERD5 protein, human
0
*Receptors, Estrogen
Antigens
Breast Neoplasms
Tumor Markers, Biological.
Eur J Gynaecol Oncol 1989;10(2):141
estrophilin platinum complex
0
*Carrier Proteins
*Organoplatinum Compounds
Receptors, Estrogen.
Virchows Arch [B[ 1987;53(4):198
estriol receptor
0
*Receptors, Estrogen
Estriol.
J Steroid Biochem 1984;21(2):163
2-
(4-
methoxyphenyl)-
4'-
(2-
(1-
pyrrolidinyl)ethoxy)deoxybenzoin
87198-64-9
Nitromifene/*analogs & derivatives
Receptors, Estrogen/drug effects.
J Med Chem 1983;26(12):1701; Life Sci 1983;33(11):1051
estrone receptor
0
*Receptors, Estrogen
Estrone.
Hormone Res 1983;17(3):168
5S-
CA
0
*Blood Proteins
Receptors, Estrogen.
Proc Nat Acad Sci 75(6):2664;1978
4-
hydroxytamoxifen
68392-35-8 phenol, 4-
(1-
(4-
(2-
(dimethylamino)ethoxy)phenyl)-
2-
phenyl-
1-
butenyl)-
,
Tamoxifen/*analogs & derivatives
Receptors, Estrogen/agonists.
Pharma Action
Estrogen Antagonists
Adv Exp Med Biol 117:133;1979; Biochem Biophys Res Commun 1979;91(3):812; J Endocrinol 76(2):363;1978; J Endocrinol 78(1):71;1978; J Steroid Biochem 1979;11(1A):285
estrophilin
0
*Carrier Proteins
*Receptors, Estrogen
Fungal Proteins.
Arch Surg 112(2):183;1977; Clin Chem 24(10):1848;1978; Phys Chem Basic Biol Info Trans W3 IN133R:211;1974; Vitam Horm Adv Res Appl 32:89;1974