thromboxane A2 (definition)

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ψ ψ	thromboxane A2, carbocyclic under Thromboxane A2

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Definition: An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).

/biosyn /physiol permitted

Other names Rabbit Aorta Contracting Substance; A2, Thromboxane

Substance	CAS Registry & name	Categories	Source	Drugs*
thromboxane A2, carbocyclic [ 2 beta-(Z),3 alpha-(1E,3R)-3-(3-hydroxy-(1-octenyl)bicyclo(3.1.1)hept-2-yl)-5-heptenoic acid,carbocyclic thromboxane A2 ]	73543-47-2 5-Heptenoic acid, 7-(3-(3-hydroxy-1-octenyl)bicyclo(3.1.1)hept-2-yl)-, (2alpha(Z),3beta(1E,3R*))-(+-)	Thromboxane A2/analogs & derivatives Pharma Action* Platelet Aggregation Inhibitors; Vasoconstrictor Agents	Proc Natl Acad Sci USA 1980;77(3):1706

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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thromboxane A2, carbocyclic