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Thromboxane A2

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Definition: An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).  /biosyn /physiol permitted    Other names Rabbit Aorta Contracting Substance; A2, Thromboxane
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
9-fluoro-15-hydroxy-16-phenoxy-17,18,19,20-tetranor-5,13-prostadienoic acid  0   *Prostaglandins D Prostaglandins, Synthetic Thromboxane A2/agonists. Prostaglandins 1995 Aug;50(2):57
KDI 792  0   *Pyridines *Pyrrolidines Thromboxane A2/antagonists & inhibitors Thromboxane-A Synthase/antagonists & inhibitors. Prostaglandins Leukot Essent Fatty Acids 1995 Aug;53(2):139-45
ONO 11006  73509-46-3 5-Heptenoic acid, 7-(3-(3-hydroxy-1-octenyl)bicyclo(3.1.1)hept-2-yl)-, (2alpha(Z),3beta(1E,3S*))-(+-)  Thromboxane A2/*analogs & derivatives. Eur J Pharmacol 1992 Mar 17;213(1):79-85
9,11-dimethylmethano-11,12-methano-16-(3-iodo-4-azidophenyl)-13,14-dihydro-13-aza-15-tetranorthromboxane A2  121951-69-7   *Azides Thromboxane A2/*analogs & derivatives. Biochim Biophys Acta 1989;1012(2):184
10,10-difluorothromboxane A2  121573-36-2   Thromboxane A2/*analogs & derivatives. Proc Natl Acad Sci USA 1989;86(14):5600
SQ 30741  107332-47-8 5-Heptenoic acid, 7-(3-(((((1-oxoheptyl)amino)acetyl)amino)methyl)-7-oxabicyclo(2.2.1)hept-2-yl)-, (1S-(1alpha,2alpha(Z),3alpha,4alpha))  Thromboxane A2/*analogs & derivatives. J Pharmacol Exp Ther 1987;243(2):460
EP 171  115825-93-9   Thromboxane A2/*analogs & derivatives. Thromb Res 1987;46(4):509
7-(2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)heptenoic acid  104693-32-5   *Dioxanes Thromboxane A2/metabolism. J Med Chem 1987;30(1):67
SQ 28668  87983-63-9   Thromboxane A2/*analogs & derivatives. Clin Pharmacol Ther 1986;40(6):634
ONO 3708  102191-05-9 5-Heptenoic acid, 7-(3-((cyclopentylhydroxyacetyl)amino)-6,6-dimethylbicyclo(3.1.1)hept-2-yl)-, (1S-(1alpha,2beta(Z),3alpha(S*),5alpha))  Thromboxane A2/*analogs & derivatives.
Pharma Action Platelet Aggregation Inhibitors 		J Cardiovasc Pharmacol 1986;8(4):818
I-PTA-OH  97228-80-3   Thromboxane A2/*analogs & derivatives. Proc Natl Acad Sci USA 1985;82(21):7434
9,10-dimethylmethano-11,12-methano-16-(4-methoxyphenyl)-13,14-dihydro-13-aza-15-tetranorthromboxane A2  99473-03-7   Thromboxane A2/*analogs & derivatives. Mol Pharmacol 1985;28(2):163
ONO 11120  85798-84-1 5-Heptenoic acid, 7-(3-((2-hydroxy-3-phenylpropyl)amino)-6,6-dimethylbicyclo(3.1.1)hept-2-yl)  Thromboxane A2/*analogs & derivatives. Adv Prostaglandin Thromboxane Leukotriene Res 1983;11:351
ONO 11119  82402-68-4 5-Heptenoic acid, 7-(3-((2-hydroxydecyl)amino)-6,6-dimethylbicyclo(3.1.1)hept-2-yl)  Thromboxane A2/*analogs & derivatives. Adv Prostaglandin Thromboxane Leukotriene Res 1983;11:351
ONO 11105  82402-81-1 5-Heptenoic acid, 7-(3-((3-((4-ethylphenyl)thio)-2-hydroxypropyl)amino)-6,6-dimethylbicyclo(3.1.1)hept-2-yl)  Thromboxane A2/*analogs & derivatives. Adv Prostaglandin Thromboxane Leukotriene Res 1983;11:351
STA 2  80408-46-4 5-Heptenoic acid, 7-(3-(3-hydroxy-1-octenyl)-6-thiabicyclo(3.1.1)hept-2-yl)-, (1alpha,2beta(Z),3alpha(1E,3R*),5alpha)  Thromboxane A2/*analogs & derivatives. Adv Prostaglandin Thromboxane Leukotriene Res 1983;11:351
thromboxane A2, carbocyclic  73543-47-2 5-Heptenoic acid, 7-(3-(3-hydroxy-1-octenyl)bicyclo(3.1.1)hept-2-yl)-, (2alpha(Z),3beta(1E,3R*))-(+-)  Thromboxane A2/*analogs & derivatives.
Pharma Action Platelet Aggregation Inhibitors ; Vasoconstrictor Agents 		Proc Natl Acad Sci USA 1980;77(3):1706
15-hydroperoxythromboxane A2  73151-69-6 Thromboxa-5,13-dien-1-oic acid, 9,11-epoxy-15-hydroperoxy-, (5Z,9alpha,11alpha,13E,15S)  Thromboxane A2/*analogs & derivatives. J Biol Chem 255(2):518;1980
pinane-thromboxane A2  71154-83-1 (1S-(1 alpha,2 beta(Z),3 alpha(1E,3S*),5 alpha))-7-(3-(3-hydroxy-1-octenyl)-6,6-dimethylbicyclo(3.1.1)hept-2-yl)-5-heptenoic acid  Thromboxane A2/*analogs & derivatives. Proc Natl Acad Sci USA 76(6):2566;1979
RCS-RF  0   *Peptides Thromboxane A2. Br J Pharmacol 57(3):461P;1976; Nature 263(5577):479;1976

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