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Thromboxane-A Synthase

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Definition: An enzyme found predominantly in platelet microsomes. It catalyzes the conversion of PGG(2) and PGH(2) (prostaglandin endoperoxides) to thromboxane A2. EC 5.3.99.5.  found in platelet microsomes    Other names Thromboxane Synthetase; Synthetase, Thromboxane A2; Synthetase, Thromboxane; Synthase, Thromboxane-A; Synthase, Thromboxane A; A2 Synthetase, Thromboxane; Thromboxane A2 Synthetase; Thromboxane A Synthase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Nv 52 compound  0   *Flavonoids Thromboxane-A Synthase/antagonists & inhibitors. Expert Opin Investig Drugs 2007 Aug;16(8):1255-66
N-n-pentyl-N'-(2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl)urea  0   *Aniline Compounds *Sulfonylurea Compounds Thromboxane-A Synthase/antagonists & inhibitors Receptors, Thromboxane/antagonists & inhibitors. J Pharmacol Exp Ther 2005 Apr;313(1):293-301
2-(4-chlorophenylsulfonamido)-6-propyl-7-((pyridin-3-yl)methyl)-1,2,3,4-tetrahydronaphthalene-5-propanoic acid  0   *Sulfonamides *Tetrahydronaphthalenes Thromboxane-A Synthase/antagonists & inhibitors Receptors, Thromboxane/antagonists & inhibitors. Bioorg Med Chem Lett 1998 Jun 2;8(11):1381-6
7-(4-(4-(((4-cyclohexylbutyl)amino)carbonyl)-2-oxazolyl)phenyl)-7-(3-pyridyl)hept-6-enoic acid  0   *Heptanoic Acids *Oxazoles Thromboxane-A Synthase/antagonists & inhibitors Receptors, Thromboxane/antagonists & inhibitors. J Med Chem 1998 Dec 31;41(27):5362-74
DTTX30  0   *Pyridines *Chlorobenzenes Thromboxane-A Synthase/antagonists & inhibitors Receptors, Thromboxane/antagonists & inhibitors. Basic Res Cardiol 1997 Jun;92(3):181-90
NQ Y15  0   *Naphthoquinones Thromboxane-A Synthase/antagonists & inhibitors. Biochem Pharmacol 1997 Jul 15;54(2):259-68
MED 27  104333-87-1   Theophylline/*analogs & derivatives Thromboxane-A Synthase/antagonists & inhibitors. Arzneimittelforschung 1996 Jan;46(1):35-41
BW 149H  0   *Organic Chemicals Thromboxane-A Synthase/antagonists & inhibitors. Gen Pharmacol 1996 Apr;27(3):519-23
camonagrel  105920-77-2   *Indans Thromboxane-A Synthase/antagonists & inhibitors. Methods Fin Exp Clin Pharmacol 1996 Apr;167-74
KF 13218  127654-03-9   *Benzazepines Thromboxane-A Synthase/antagonists & inhibitors. Arzneimittelforschung 1995 Oct;45(10):1066-70
KDI 792  0   *Pyridines *Pyrrolidines Thromboxane A2/antagonists & inhibitors Thromboxane-A Synthase/antagonists & inhibitors. Prostaglandins Leukot Essent Fatty Acids 1995 Aug;53(2):139-45
E 3040  145096-30-6   *Pyridines *Benzothiazoles Thromboxane-A Synthase/antagonists & inhibitors. J Pharmacol Exp Ther 1995 Sep;274(3):1362-9
7-(4-((4-(5-(5-carboxypent-2-enyl)-4-(2-hydroxyphenyl)-1,3-dioxan-2-yl)benzyl)oxy)phenyl)-7-(3-pyridyl)hept-6-enoic acid  0   *Dioxanes Thromboxane-A Synthase/antagonists & inhibitors. J Med Chem 1995 May 12;38(10):1608-28
ONO AP 500-02  0   *Acetic Acids *Pyridines Thromboxane-A Synthase/antagonists & inhibitors. Adv Prostaglandin Thromboxane Leukot Res 1995;23:401-3
cinnamophilin  154677-96-0   *Lignans Guaiacol/*analogs & derivatives Thromboxane-A Synthase/antagonists & inhibitors. Br J Pharmacol 1994 Mar;111(3):906-12
FCE 27262  142223-40-3   *Imidazoles *Pentanoic Acids Thromboxane-A Synthase/antagonists & inhibitors. Drugs Exp Clin Res 1993;19(6):249-60
6-(4-(2-(((4-chlorophenyl)sulfonyl)amino)ethyl)phenyl)-6-(3-pyridyl)hex-5-enoic acid  133276-80-9   *Fatty Acids, Unsaturated *Pyridines Thromboxane-A Synthase/antagonists & inhibitors. J Med Chem 1994 Jan 7;37(1):26-39
2-methyl-4-(5-thiazolyl)-1(2H)-phthalazinone  137382-10-6   *Phthalazines *Thiazoles Thromboxane-A Synthase/antagonists & inhibitors. J Med Chem 1993 Dec 10;36(25):4061-8
2-ethyl-4-(3-pyridyl)-1(2H)-phthalazinone  137381-66-9   *Phthalazines *Pyridines Thromboxane-A Synthase/antagonists & inhibitors. J Med Chem 1993 Dec 10;36(25):4061-8
2-(2-(1-imidazolyl)ethyl)-4-(3-pyridyl)-1(2H)-phthalazinone  137381-31-8   *Imidazoles *Phthalazines Thromboxane-A Synthase/antagonists & inhibitors. J Med Chem 1993 Dec 10;36(25):4052-60
2,8-bis(3'-pyridylmethyl)-6H,12H-5,11-methanodibenzo(b,f)(1,5)diazocine  0   *Azocines *Pyridines Thromboxane-A Synthase/antagonists & inhibitors. J Med Chem 1993 Oct 15;36(21):3202-6
Troeger's base  529-81-7   *Azocines Thromboxane-A Synthase/antagonists & inhibitors. J Med Chem Oct 15;36(21):3202-6
FCE 24265  148612-84-4   *Dihydropyridines *Imidazoles Thromboxane-A Synthase/antagonists & inhibitors. J Med Chem 1993 Oct 1;36(20):2964-72
ICI D1542  147332-48-7 4-Hexenoic acid, 6-(2-(1-methyl-1-(4-methyl-2-nitrophenoxy)ethyl)-4-(3-pyridinyl)-1,3-dioxan-5-yl)-, (2S-(2alpha,4alpha,5alpha(Z)))  *Dioxanes *Pyridines Thromboxane-A Synthase/antagonists & inhibitors. Br J Pharmacol 1993 Apr;108(4):901-6
CGS 22652  134235-78-2   *Octanoic Acids *Sulfonamides Thromboxane-A Synthase/antagonists & inhibitors. J Med Chem 1992 Nov 13;35(23):4373-83
8-(benzenesulfonamido)-7-(3-pyridinyl)octanoic acid  134162-37-1   *Octanoic Acids *Sulfonamides Thromboxane-A Synthase/antagonists & inhibitors. J Med Chem 1992 Nov 13;35(23):4362-5
3-carbamyl-(3'-picolyl)-4-methoxy-1-benzamide  108828-56-4 1,3-Benzenedicarboxamide, 4-methoxy-N3-(3-pyridinylmethyl)  *Benzamides *Picolines Thromboxane-A Synthase/antagonists & inhibitors. J Cardiovasc Pharmacol 1992 Jan;19(1):60-8
CV 6504  117574-40-0   *Benzoquinones Thromboxane-A Synthase/antagonists & inhibitors. Adv Prostaglandin Thromboxane Leukotriene Res 1991;21A:173
rolafagrel  89781-55-5   *Imidazoles *Naphthalenes Thromboxane-A Synthase/antagonists & inhibitors. Kidney Int 1990;38(3):447
ridogrel  110140-89-1 Pentanoic acid, 5-(((3-pyridinyl(3-(trifluoromethyl)phenyl)methylene)amino)oxy)-, (E)  *Pentanoic Acids *Pyridines Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Gastrointestinal Agents ; Platelet Aggregation Inhibitors 		Thromb Haemost 1989;61(1):35
Wy 27569  103417-69-2 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-(1H-imidazol-1-ylmethyl)-6-methyl-4-(3-nitrophenyl)-, 3-ethyl 5-methyl ester  *Dihydropyridines Thromboxane-A Synthase/antagonists & inhibitors. J Cardiovasc Pharmacol 1989;13(4):511
6-(5-methylimidazol-1-yl)methyl-2-naphthoic acid hydrochloride  105523-24-8   *Imidazoles *Naphthalenes Thromboxane-A Synthase/antagonists & inhibitors. Biomed Biochim Acta 1988;47(10-11):S23
RS 86328  116766-08-6   Thromboxane-A Synthase/*antagonists & inhibitors. Proc West Pharmacol Soc 1988;31:81
2-(2-dimethylaminoethyl)-5-benzylidene-6-methyl-3-pyridazinone  117027-28-8   *Benzyl Compounds *Pyridazines Thromboxane-A Synthase/antagonists & inhibitors. Prostaglandins Leukot Essent Fatty Acids 1988;33(2):143
nafagrel  97901-21-8   *Imidazoles *Tetrahydronaphthalenes Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		J Chromatogr 1988;426(1):111
RS 5186  113817-57-5 Benzo(b)thiophene-6-carboxylic acid, 4,5-dihydro-2-(1H-imidazol-1-ylmethyl)-, sodium salt  *Thiophenes Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Platelet Aggregation Inhibitors ; Neuroprotective Agents 		Arzneimittelforschung 1988;38(2):224
Y 19018  88941-45-1 Benzenemethanol, alpha-(5-(1H-imidazol-1-yl)-2-methylphenyl)-2,4,6-trimethyl  *Imidazoles Thromboxane-A Synthase/antagonists & inhibitors. Jpn J Pharmacol 1987;45(2):177
Ro 23-3423  110996-51-5   *Quinazolines Thromboxane-A Synthase/antagonists & inhibitors. Prostaglandins 1987;33(6):879
1-(2,3-bis((4-methoxyphenyl)methoxy)propyl)-1H-imidazole  84750-41-4 1H-Imidazole, 1-(2,3-bis((4-methoxyphenyl)methoxy)propyl)  *Imidazoles Thromboxane-A Synthase/antagonists & inhibitors. Thromb Res 1987;46(4):555
5-chloro-1-methyl-2-(3-pyridyl)-3-indolehexanoic acid  107190-22-7 1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)-, monohydrochloride  *Indoles Thromboxane-A Synthase/antagonists & inhibitors. Eur J Pharmacol 1987;133(3):265
Y 20811  104363-98-6 Benzoic acid, 4-(hydroxy(5-(1H-imidazol-1-yl)-2-methylphenyl)methyl)-3,5-dimethyl-, monosodium salt  *Imidazoles Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Fibrinolytic Agents 		Thromb Res 1986;43(4):455
3-methyl-2-(3-pyridyl)-1-indoleoctanoic acid  87627-28-9 1H-Indole-1-octanoic acid, 3-methyl-2-(3-pyridinyl)  *Pyridines Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Uricosuric Agents 		Br J Pharmacol 1985;86(2):497
1-(3-benzyloxy-1(E)octenyl)imidazole  80614-27-3   *Imidazoles Thromboxane-A Synthase/antagonists & inhibitors. Arzneimittelforschung 1986;36(11):117
LG 82-4-01  91505-19-0 2-Thiophenecarboxylic acid, 4-chloro-5-(2-(1H-imidazol-1-yl)ethoxy)-, monohydrochloride  *Thiophenes Thromboxane-A Synthase/antagonists & inhibitors. Eur J Pharmacol 1985;112(2):161
LG 82-4-00  91505-18-9 2-Thiophenecarboxylic acid, 5-(2-(1H-imidazol-1-yl)ethoxy)-, monohydrochloride  *Thiophenes Thromboxane-A Synthase/antagonists & inhibitors. Eur J Pharmacol 1985;112(2):161
isbogrel  89667-40-3 6-Heptenoic acid, 7-phenyl-7-(3-pyridinyl)-, (E)  *Fatty Acids, Monounsaturated *Pyridines Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Fibrinolytic Agents 		Eur J Pharmacol 1985;109(2):135
furegrelate  85666-17-7   *Benzofurans Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Prostaglandins 1983;26(2):311
dazmegrel  76894-77-4 1H-Indole-1-propanoic acid, 3-(1H-imidazol-1-ylmethyl)-2-methyl  *Imidazoles Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Platelet Aggregation Inhibitors ; Vasodilator Agents 		Circulation 1983;68(4):821
Ro 22-4679  86003-82-9 Ro 22-4679  *Imidazoles Thromboxane-A Synthase/antagonists & inhibitors. Circ Res 1983;52(5):608
4-((2-pyridinylmethyl)amino)benzoic acid  5966-18-7   *Aminobenzoic Acids Thromboxane-A Synthase/antagonists & inhibitors. Br J Pharmacol 1983;74(8):725
4-((3-pyridinylmethyl)amino)benzoic acid  5966-19-8   *Aminobenzoic Acids Thromboxane-A Synthase/antagonists & inhibitors. Br J Pharmacol 1983;74(8):725
pirmagrel  85691-74-3 Imidazo(1,5-a)pyridine-5-hexanoic acid  *Imidazoles *Pyridines Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Immunosuppressive Agents 		Biochem Biophys Res Commun 1983;112(3):899
Ro 22-3581  10041-06-2   *Imidazoles Thromboxane-A Synthase/antagonists & inhibitors. Prostaglandins 1982;23(1):273
ozagrel  82571-53-7 2-Propenoic acid, 3-(4-(1H-imidazol-1-ylmethyl)phenyl)-, (E)  *Methacrylates Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Fibrinolytic Agents ; Histamine Antagonists 		Jpn Heart J 1981;22(6):971
1-carboxyheptylimidazole  68887-68-3   *Imidazoles Thromboxane-A Synthase/antagonists & inhibitors. Thromb Res 1981;21(4-):413
2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-2-propenoic acid  75987-08-5 2-propenoic acid, 2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-,  *Methacrylates Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Eur J Pharmacol 1981;69(4):533; No To Shinkei 1981;33(11):1147
imidazole  288-32-4   *Imidazoles Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Prostaglandins 1981;21(3):401
UK 34787  72818-36-1 1H-indole, 3-(1H-imidazol-1-ylmethyl)-2-(1-methylethyl)  *Indoles Thromboxane-A Synthase/antagonists & inhibitors. Thromb Res 1980;20(2):219
dazoxiben  78218-09-4 Benzoic acid, 4-(2-(1H-imidazol-1-yl)ethoxy)  *Imidazoles Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Lancet 1981;1(8221):629
N 0164  60787-00-0 (phenylmethyl)phosphonic acid, mono(4-(2-((4-chlorophenyl)methyl)-1-oxo-3-phenylpropyl)phenyl) ester, sodium salt  *Phosphonic Acids Thromboxane-A Synthase/antagonists & inhibitors. Biochim Biophys Acta 531(3):286;1978; Br J Pharmacol 58:333;1976; Br J Pharmacol 60(2):293P;1977; Br J Pharmacol 60:135;1977; J Endocrinol 75(2):335;1977; Prostaglandins 12(3):465;1976; Prostaglandins 14(5):897;1977; Prostaglandins 16(3):373;1978; Thromb Res 11:705;1977; Urology 12(6):674;1978
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