Definition: A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.
alkyating antineoplastics; do not confuse with NITROGEN MUSTARD, a specific chemical; DF: NITROGEN MUSTARD CPDS
Other names Mustard Compounds, Nitrogen; Compounds, Nitrogen Mustard
xylamine [ N-2-chloroethyl-N-ethyl-2-methylbenzylamine ] irreversibly inhibits norepinephrine accumulation by rabbit aortic rings in vitro; UD & journal source given agree on structure of cpd; Negwer calls it the bis(2-chloroethyl) cpd