Definition: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).
Other names Vitamin A Acid; Retinoic Acid; trans Retinoic Acid; beta all trans Retinoic Acid; all trans Retinoic Acid; Zinc Salt, Tretinoin; Sodium Salt, Tretinoin; Salt, Tretinoin Zinc; Salt, Tretinoin Sodium; Salt, Tretinoin Potassium; Retin A; Potassium Salt, Tretinoin; Acid, trans-Retinoic; Acid, beta-all-trans-Retinoic; Acid, all-trans-Retinoic; Acid, Vitamin A; Acid, Retinoic; trans-Retinoic Acid; beta-all-trans-Retinoic Acid; all-trans-Retinoic Acid
3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid [ E5166,3,7,11,15-tetramethyl-trans-2,4,6,10,14-hexadecapentaenoic acid,E 5166,TMHDP,acyclic retinoid,polyprenoic acid ] has strong binding affinity to cellular retinoic acid-binding protein; RN given refers to (trans)-isomer; structure given in first source