Definition: A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.
monorden [ 5-chloro-6-(7,8-epoxy-10-hydroxy-2-oxo-3,5-undecadienyl)-beta-resorcylic acid mu-lactone,KF58332,KF9-A,monordene,radicicol ] inhibits HSP90 Heat-Shock Proteins, DNA topoisomerase VI and human Topoisomerase II