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lipoprotein-associated coagulation inhibitor

under Lipoproteins
More information in Books or onNLM PubMed
More on Lipoproteins Definition: Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.  general or unspecified; prefer specifics; /blood: consider also HYPERLIPOPROTEINEMIA; /defic: consider also HYPOLIPOPROTEINEMIAS & specifics; do not confuse with PROTEOLIPIDS or LIPID-LINKED PROTEINS    Other names Lipoproteins, Circulating; Lipoprotein; Circulating Lipoproteins
SubstanceCAS Registry & nameCategoriesSourceDrugs*
lipoprotein-associated coagulation inhibitor [ EPI I (extrinsic pathway inhibitor I),LACI inhibitor,TFI HepG2,TFPI,TFPI-beta,TFPIbeta,Xa-dependent factor VIIa-TF inhibitor,anticonvertin,antithromboplastin,extrinsic pathway inhibitor I,tissue factor inhibitor, hepatoma,tissue factor pathway inhibitor ]
  MW 38,000; produced by HepG2 hepatoma & other cells; requires factor VII(a), factor X(a) & Ca++ to express inhibitory activity 		0   *Lipoproteins Factor Xa/antagonists & inhibitors
Pharma Action Anticoagulants; Fibrinolytic Agents; Serine Proteinase Inhibitors 		Proc Natl Acad Sci USA 1987;84(7):1886

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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