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tyrphostin A23
under Tyrphostins
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Tyrphostins
Definition
: A family of synthetic protein tyrosine kinase inhibitors. They selectively inhibit receptor autophosphorylation and are used to study receptor function.
Substance
CAS Registry & name
Categories
Source
Drugs
*
tyrphostin A23 [ (3,4-dihydroxybenzylidene)malononitrile,(3,4-dihydroxyphenyl)methylene propanedinitrile,3,4-dihydroxybenzylidenemalononitrile,RG 50810,RG-50810,tyrphostin 23,tyrphostin A1,tyrphostin AG18,tyrphostin RG50810 ]
inhibits EGF-stimulated thymidine incorporation as well as EGF-stimulated receptor autophosphorylation & tyrosine phosphorylation & cell proliferation; structure given in first source
118409-57-7
*Tyrphostins
Protein-Tyrosine Kinases/antagonists & inhibitors
Pharma Action
Antineoplastic Agents
;
Enzyme Inhibitors
J Biol Chem 1989;264(24):14503
