Definition: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
2-amino-4-methyl-5-phosphono-3-pentenoic acid [ 2-amino-4-methyl-5-phosphono-3-pentenoic acid, (E)-isomer,2-amino-4-methyl-5-phosphono-3-pentenoic acid, E(+-)-isomer,2-amino-4-methyl-5-phosphono-3-pentenoic acid, R-(E)-isomer,2-amino-4-methyl-5-phosphono-3-pentenoic acid, S-(E)-isomer,4-methyl-APPA,CGP 37849,CGP 40017,CGP 40116,CGP-37849,CGP-40017,CGP-40116,CGP40.116 ] N-methyl-D-aspartate receptor antagonist; structure given in first source; RN given refers to cpd without isomeric designation; CGP-40116 is the (R)-enantiomer of CGP-37849; CGP-40017 is the L-isomer