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2-amino-4-methyl-5-phosphono-3-pentenoic acid

under 2-Amino-5-phosphonovalerate
More information in Books or onNLM PubMed
More on 2-Amino-5-phosphonovalerate Definition: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.      Other names 2 Amino 5 phosphonopentanoate; dl-APV; d-APV; 5-Phosphononorvaline; 2-Amino-5-phosphonopentanoate; 2-Amino-5-phosphonovaleric Acid; 2-Amino-5-phosphonopentanoic Acid; 2-APV; 5 Phosphononorvaline; 2 Amino 5 phosphonovaleric Acid; 2 Amino 5 phosphonovalerate; 2 Amino 5 phosphonopentanoic Acid
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-amino-4-methyl-5-phosphono-3-pentenoic acid [ 2-amino-4-methyl-5-phosphono-3-pentenoic acid, (E)-isomer,2-amino-4-methyl-5-phosphono-3-pentenoic acid, E(+-)-isomer,2-amino-4-methyl-5-phosphono-3-pentenoic acid, R-(E)-isomer,2-amino-4-methyl-5-phosphono-3-pentenoic acid, S-(E)-isomer,4-methyl-APPA,CGP 37849,CGP 40017,CGP 40116,CGP-37849,CGP-40017,CGP-40116,CGP40.116 ]
  N-methyl-D-aspartate receptor antagonist; structure given in first source; RN given refers to cpd without isomeric designation; CGP-40116 is the (R)-enantiomer of CGP-37849; CGP-40017 is the L-isomer 		137424-81-8 3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (E)-(+-)  2-Amino-5-phosphonovalerate/*analogs & derivatives
Pharma Action Anticonvulsants; Excitatory Amino Acid Antagonists 		Br J Pharamcol 1990;99(4):791

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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