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2-Amino-5-phosphonovalerate

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Definition: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.     
Pharmacological Action Excitatory Amino Acid Antagonists 		Other names 2 Amino 5 phosphonopentanoate; dl-APV; d-APV; 5-Phosphononorvaline; 2-Amino-5-phosphonopentanoate; 2-Amino-5-phosphonovaleric Acid; 2-Amino-5-phosphonopentanoic Acid; 2-APV; 5 Phosphononorvaline; 2 Amino 5 phosphonovaleric Acid; 2 Amino 5 phosphonovalerate; 2 Amino 5 phosphonopentanoic Acid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-amino-5-phosphono-3-pentenoic acid  118492-04-9   2-Amino-5-phosphonovalerate/*analogs & derivatives. J Antibiot (Tokyo) 1995 Sep;48(9):1043-5
CGP 43487  146388-56-9   2-Amino-5-phosphonovalerate/*analogs & derivatives. J Comp Neurol 1994 Feb 22;340(4):551-65
CGP 39653  132472-31-2 3-Heptenoic acid, 2-amino-4-(phosphonomethyl)-, (E)-(+-)  2-Amino-5-phosphonovalerate/*analogs & derivatives.
Pharma Action Excitatory Amino Acid Antagonists 		Eur J Pharmacol 1991;192(1):19
CGP 39551  127910-32-1 3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, 1-ethyl ester, (E)-(+-)  2-Amino-5-phosphonovalerate/*analogs & derivatives.
Pharma Action Anticonvulsants ; Excitatory Amino Acid Antagonists 		Br J Pharmacol 1990;99(4):791
2-amino-4-methyl-5-phosphono-3-pentenoic acid  137424-81-8 3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (E)-(+-)  2-Amino-5-phosphonovalerate/*analogs & derivatives.
Pharma Action Anticonvulsants ; Excitatory Amino Acid Antagonists 		Br J Pharamcol 1990;99(4):791
2-amino-7-phosphonoheptanoic acid  85797-13-3 Heptanoic acid, 2-amino-7-phosphono-, (+-)  2-Amino-5-phosphonovalerate/*analogs & derivatives.
Pharma Action Anticonvulsants ; Excitatory Amino Acid Antagonists 		Neurosci lett 1981;23(3):333

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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