Definition: A family of synthetic protein tyrosine kinase inhibitors. They selectively inhibit receptor autophosphorylation and are used to study receptor function.
tyrphostin 25 [ (3,4,5-trihydroxybenzylidene)-malononitrile,tyrphostin A25,tyrphostin-25 ] inhibits zymosan-stimulated PGE2 & LTC4 production; did not have any effect on human synovial fluid phospholipase A2 activity in vitro or on cyclooxygenase activity in the intact macrophage; did affec
