Definition: An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
exatecan [ (1S,9S)-1-amino-9-ethyl-5-fluoro-2,3-dihydro-9-hydroxy-4-methyl-1H,12H-benzo(de)pyrano(3',4'-6,7)indolizino(1,2-b)quinoline-10,13(9H,15H)dione methanesulfonate,DX 8951,DX 8951f,DX-8951,DX-8951a,DX-8951f,exatecan mesylate ] DX-8951a is hydrochloride & DX-895If is methanesulfonate; exatecan mesylate is a synonym for DX-8951f; structure given in first and second source