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rofecoxib

under Lactones
More information in Books or onNLM PubMed
More on Lactones Definition: Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.  pyran-2-ones: index PYRONES + LACTONES but BENZOPYRAN-2-ONES is available; for cyclic lactones over 12 atoms consider MACROLIDES   
SubstanceCAS Registry & nameCategoriesSourceDrugs*
rofecoxib [ Cahill May Roberts brand of rofecoxib,MK 0966,MK 966,MK-0966,MK-966,MSD brand of rofecoxib,Merck Frosst brand of rofecoxib,Merck Sharp & Dhome brand of rofecoxib,Merck brand of rofecoxib,Vioxx,Vioxx Dolor,refecoxib ]
  a sulfonylphenyl furanone; withdrawn out of concern for TOXICITY 		0 4-(4-methylsulfonylphenyl)-3-phenyl-5H-furan-2-one  *Lactones *Sulfones
Pharma Action Cyclooxygenase 2 Inhibitors 		Lancet 1999 Jan 23;353(9149):307-14 VIOXX

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