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sunitinib
under Indoles
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Indoles
Definition
: Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
Substance
CAS Registry & name
Categories
Source
Drugs
*
sunitinib [ 5-(5-fluoro-2-oxo-1,2-dihydroindolylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide,SU 011248,SU 11248,SU-011248,SU-11248,SU011248,SU11248,Sutent,sunitinib malate ]
inhibits VEGF-R2 and PDGF-Rbeta tyrosine kinase; has antineoplastic activity; structure in first source
0
*Indoles
*Pyrroles
Pharma Action
Antineoplastic Agents
;
Angiogenesis Inhibitors
J Med Chem 2003 Mar 27;46(7):1116-9
SUTENT