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Calcimycin

More information in Books or onNLM PubMed
Definition: An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.     
Pharmacological Action Anti-Bacterial Agents; Calcium Ionophores 		Other names A 23187; A23187; A23187, Antibiotic; Antibiotic A23187; A-23187
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-hydroxycezomycin  104414-30-4   Calcimycin/*analogs & derivatives. J Antibiot (Tokyo) 1987;40(2):239
cezomycin  83874-22-0   Calcimycin/*analogs & derivatives Ionophores. J Antibiot (Tokyo) 1982;35(10):1409
4-bromo-A-23187  76455-48-6 4-Benzoxazolecarboxylic acid, 6-bromo-5-(methylamino)-2-((3,9,11-trimethyl-8-(1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)methyl)-, (6S-(6alpha(2S*,3S*),8beta(R*),9beta,11alpha))  Calcimycin/*analogs & derivatives Ionophores. Biochemistry 1981;20(24):6865

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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