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Cholesterol Side-Chain Cleavage Enzyme

More information in Books or onNLM PubMed
Definition: A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.      Other names Cytochrome P-450(scc); Cytochrome P-450 CYP11A1; Cholesterol Monooxygenase (Side-Chain-Cleaving); Cholesterol Desmolase; CYP11A1; Cytochrome P 450 CYP11A1; Cholesterol Side Chain Cleavage Enzyme; 20,22 Desmolase; Cytochrome P450scc; Cytochrome P450 11A1; CYP 11A1; 20,22-Desmolase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
22-thio-23,24-bisnor-5-cholen-3-ol  116523-89-8   *Pregnenes Cholesterol Side-Chain Cleavage Enzyme/antagonists & inhibitors. J Steroid Biochem 1988;29(5):539
20-(1,5-hexadiynyl)-5-pregnen-3,20-diol  86532-89-0 Pregn-5-ene-3,20-diol, 20-(1,5-hexadiynyl)-, (3beta,20R)  Pregnenolone/*analogs & derivatives Cholesterol Side-Chain Cleavage Enzyme/antagonists & inhibitors. J Biol Chem 1983;258(11):6721
20-(1-hexynyl)-5-pregnen-3,20-diol  86532-88-9 Pregn-5-ene-3,20-diol, 20-(1-hexynyl)-, (3beta,20R)  Pregnenolone/*analogs & derivatives Cholesterol Side-Chain Cleavage Enzyme/antagonists & inhibitors. J Biol Chem 1983;258(11):6721
20-(1-propynyl)-5-pregnen-3,20-diol  86562-07-4 Chol-5-en-22-yne-3,20-diol, (3beta)  Pregnenolone/*analogs & derivatives Cholesterol Side-Chain Cleavage Enzyme/antagonists & inhibitors. J Biol Chem 1983;258(11):6721

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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