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Diazooxonorleucine
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Definition
: An amino acid that inhibits phosphate-activated glutaminase and interferes with glutamine metabolism. It is an antineoplastic antibiotic produced by an unidentified species of Streptomyces from Peruvian soil. (From Merck Index, 11th ed)
Pharmacological Action
Antibiotics, Antineoplastic
;
Antimetabolites, Antineoplastic
Other names
6 Diazo 5 oxo L norleucine; 6-
Diazo-
5-
oxo-
L-
norleucine
Substance
CAS Registry & name
Categories
Source
Drugs
*
6-
diazo-
5-
oxo-
L-
norleucylglycine
78081-74-0 Glycine, N-
(6-
diazo-
5-
oxo-
L-
norleucyl)
Diazooxonorleucine/*analogs & derivatives
gamma-Glutamyltransferase/antagonists & inhibitors.
Proc Natl Acad Sci USA 1981;78(1):46