20-alpha-Dihydroprogesterone (definition)

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ψ ψ	20-alpha-Dihydroprogesterone

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Definition: A biologically active 20-alpha-reduced metabolite of PROGESTERONE. It is converted from progesterone to 20-alpha-hydroxypregn-4-en-3-one by the 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE in the CORPUS LUTEUM and the PLACENTA.

Pharmacological Action Progestins

Other names Dihydroprogesterone; Pregn 4 en 3 one, 20 alpha hydroxy; 20alpha Hydroxypregn 4 Ene 3 One; 20-alpha-hydroxy- Pregn-4-en-3-one; 20 alpha Hydroxyprogesterone; 20 alpha Hydroxy 4 Pregnen 3 One; 20 alpha Dihydroprogesterone; Pregn-4-en-3-one, 20-alpha-hydroxy; 20alpha-Hydroxypregn-4-Ene-3-One; 20-alpha-Hydroxyprogesterone; 20 alpha-Hydroxyprogesterone; 20 alpha-Hydroxy-4-Pregnen-3-One; 20 alpha-Dihydroprogesterone

Substance	CAS Registry & name	Categories	Source
3-hydroxypregn-4-en-20-one	25680-68-6	20-alpha-Dihydroprogesterone/*analogs & derivatives.	Endocrinology 1987;120(6):2259
11-beta-hydroxy-20-alpha-dihydroprogesterone	15137-31-2	20-alpha-Dihydroprogesterone/*analogs & derivatives.	Proc Nat Acad Sci USA 70(10):2753;1973
20 beta-dihydroprogesterone	15114-79-1 (20R)-20-hydroxypregn-4-en-3-one	*20-alpha-Dihydroprogesterone Isomerism.	Biol Reprod 1(1):49;1969; Biol Reprod 14(5):572;1976; Gen Comp Endocrinol 24(4):352;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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