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Diphenoxylate

More information in Books or onNLM PubMed
Definition: A MEPERIDINE congener used as an antidiarrheal, usually in combination with ATROPINE. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity.     
Pharmacological Action Analgesics, Opioid; Antidiarrheals 		Other names Monohydrochloride, Diphenoxylate; Hydrochloride, Diphenoxylate; Diphenoxylate Monohydrochloride; Diphenoxylate Hydrochloride
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
difenoxin  28782-42-5   Diphenoxylate/*analogs & derivatives.
Lyspafen  79568-96-0 4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, mixt. with endo-(+-)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl alpha-(hydroxymethyl)benzeneacetate sulfate (2:1) (salt)  *Atropine *Diphenoxylate Drug Combinations. Aust Fam Physician 1980;9(12):874
difenoximide  37800-79-6 n-hydroxysuccinimide diphenoxylate  Diphenoxylate/*analogs & derivatives. Am J Drug Alcohol Abuse 4(1):123;1977; Drug Addiction Vol 3 Neurobiol Influences on Behavior W3 IN197KC 1973d p. 309
atropine sulfate-diphenoxylate hydrochloride combination  55840-97-6 4-piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, monohydrochloride, mixt. with endo-(+-)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl alpha-(hydroxymethyl)benzeneacetate sulfate (2:1) (salt)  *Atropine *Diphenoxylate Drug Combinations.
Pharma Action Gastrointestinal Agents 		Br Med J 6054(1):167;1977; Clin Pediatr 12(1):47;1973; Farmakol Toksikol 38(2):200;1975; Harefuah 1979;97(5-6):125; Lancet 1(8121):875;1979; Pediatrics 1980;65(1):157; South Med J 1980;73(3):381; Ther Hung 1979;27(3):134; Vrach Delo 2:34;1978LOW-QUEL; LOMOTIL; LOGEN; DI-ATRO; DIPHENOXYLATE HYDROCHLORIDE AND ATROPINE SULFATE; LO-TROL; LOMANATE; COLONAID; LONOX

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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