Fatty Acid Synthetase Complex (definition)

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ψ ψ	Fatty Acid Synthetase Complex

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Definition: An enzyme complex of multiple catalytic domains which elongates FATTY ACIDS. The form found in BACTERIA; FUNGI; and PLANTS is different from the form found in ANIMALS. The complex is a target of some ANTINEOPLASTIC AGENTS, some ANTI-OBESITY AGENTS, and some ANTI-INFECTIVE AGENTS.

do not confuse with FAS-ASSOCIATED DEATH DOMAIN PROTEIN or FAS LIGAND PROTEIN
Examples Fatty Acid Synthetase Complex, Type II

Other names Fatty Acid Synthase; Synthase, Fatty Acid; Acid Synthase, Fatty; FASN (Fatty Acid Synthase)

Substance	CAS Registry & name	Categories	Source
BI 99179	0	Benzoxazoles Proline/analogs & derivatives Fatty Acid Synthetase Complex/antagonists & inhibitors.	Bioorg Med Chem Lett. 2011 Oct 1;21(19):5924-7.
cajyphenol B	0	Indenes Resorcinols Fatty Acid Synthetase Complex/antagonists & inhibitors.	Chem Biodivers 2010 Dec;7(12):2931-40
cajyphenol A	0	Indenes Resorcinols Fatty Acid Synthetase Complex/antagonists & inhibitors.	Chem Biodivers 2010 Dec;7(12):2931-40
GSK837149A	0	*Sulfonamides Fatty Acid Synthetase Complex/antagonists & inhibitors.	FEBS J 2008 Apr;275(7):1556-67
FAS1 protein, S cerevisiae	EC 6.-	Fatty Acid Synthetase Complex Saccharomyces cerevisiae Proteins.	Free Radic Biol Med 2007 Nov 15;43(10):1458-65
beta-ketoacyl-ACP synthase A-condensing enzyme	EC 2.3.1	*Fatty Acid Synthetase Complex.
hexanoate synthase	EC 6.-	*Fatty Acid Synthetase Complex.	Bioorg Chem. 2001 Oct;29(5):293-307
Pks12 protein, Mycobacterium tuberculosis	EC 6.-	Bacterial Proteins Fatty Acid Synthetase Complex.	J Exp Med 2004 Dec 20;200(12):1559-69
Pks2 protein, Mycobacterium tuberculosis	EC 6.-	Bacterial Proteins Fatty Acid Synthetase Complex.	J Biol Chem 2001 May 18;276(20):16833-9
fatty acid synthase I, mycobacteria	EC 6.4.-	Bacterial Proteins Fatty Acid Synthetase Complex.	Nat Med 2000 Sep;6(9):977-8
4-methylene-2-octyl-5-oxofuran-3-carboxylic acid	0	4-Butyrolactone/*analogs & derivatives Fatty Acid Synthetase Complex/antagonists & inhibitors.	Proc Natl Acad Sci U S A 2000 Mar 28;97(7):3450-4
Fas-1A protein, Aspergillus parasiticus	0	Fatty Acid Synthetase Complex Fungal Proteins.	Appl Environ Microbiol 1996 Jan;62(1):191-5
HPR protein, human	0	Antigens, Neoplasm Haptoglobins Fatty Acid Synthetase Complex Pregnancy Proteins Tumor Markers, Biological.	Proc Natl Acad Sci USA 1989;86(4):1188
short chain trans-2-enoyl-CoA reductase	EC 1.3.1.-	Fatty Acid Synthetase Complex NADH, NADPH Oxidoreductases.	J Biol Chem 1982; 257(23):14333
mycolate synthetase	EC 6.-	*Fatty Acid Synthetase Complex.	Am Rev Respir Dis 110(1):1974
thioesterase II	EC 3.1.2.-	Fatty Acid Synthetase Complex Thiolester Hydrolases.	J Biol Chem 254(18):8932;1979; J Dairy Sci 1980;63(2):337
beta-ketoacyl thioester reductase	EC 1.1.1.-	Alcohol Oxidoreductases Fatty Acid Synthetase Complex.	Biomed Mass Spec 5(5):357;1978; J Biol Chem 249(5):1654;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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