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Fatty Acid Synthetase Complex

More information in Books or onNLM PubMed
Definition: An enzyme complex of multiple catalytic domains which elongates FATTY ACIDS. The form found in BACTERIA; FUNGI; and PLANTS is different from the form found in ANIMALS. The complex is a target of some ANTINEOPLASTIC AGENTS, some ANTI-OBESITY AGENTS, and some ANTI-INFECTIVE AGENTS.  do not confuse with FAS-ASSOCIATED DEATH DOMAIN PROTEIN or FAS LIGAND PROTEIN   
Examples Fatty Acid Synthetase Complex, Type II
Other names Fatty Acid Synthase; Synthase, Fatty Acid; Acid Synthase, Fatty; FASN (Fatty Acid Synthase)
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
BI 99179  0   *Benzoxazoles Proline/*analogs & derivatives Fatty Acid Synthetase Complex/antagonists & inhibitors. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5924-7.
cajyphenol B  0   *Indenes *Resorcinols Fatty Acid Synthetase Complex/antagonists & inhibitors. Chem Biodivers 2010 Dec;7(12):2931-40
cajyphenol A  0   *Indenes *Resorcinols Fatty Acid Synthetase Complex/antagonists & inhibitors. Chem Biodivers 2010 Dec;7(12):2931-40
GSK837149A  0   *Sulfonamides Fatty Acid Synthetase Complex/antagonists & inhibitors. FEBS J 2008 Apr;275(7):1556-67
FAS1 protein, S cerevisiae  EC 6.-   *Fatty Acid Synthetase Complex *Saccharomyces cerevisiae Proteins. Free Radic Biol Med 2007 Nov 15;43(10):1458-65
beta-ketoacyl-ACP synthase A-condensing enzyme  EC 2.3.1   *Fatty Acid Synthetase Complex.
hexanoate synthase  EC 6.-   *Fatty Acid Synthetase Complex. Bioorg Chem. 2001 Oct;29(5):293-307
Pks12 protein, Mycobacterium tuberculosis  EC 6.-   *Bacterial Proteins *Fatty Acid Synthetase Complex. J Exp Med 2004 Dec 20;200(12):1559-69
Pks2 protein, Mycobacterium tuberculosis  EC 6.-   *Bacterial Proteins *Fatty Acid Synthetase Complex. J Biol Chem 2001 May 18;276(20):16833-9
fatty acid synthase I, mycobacteria  EC 6.4.-   *Bacterial Proteins *Fatty Acid Synthetase Complex. Nat Med 2000 Sep;6(9):977-8
4-methylene-2-octyl-5-oxofuran-3-carboxylic acid  0   4-Butyrolactone/*analogs & derivatives Fatty Acid Synthetase Complex/antagonists & inhibitors. Proc Natl Acad Sci U S A 2000 Mar 28;97(7):3450-4
Fas-1A protein, Aspergillus parasiticus  0   *Fatty Acid Synthetase Complex *Fungal Proteins. Appl Environ Microbiol 1996 Jan;62(1):191-5
HPR protein, human  0   *Antigens, Neoplasm *Haptoglobins Fatty Acid Synthetase Complex Pregnancy Proteins Tumor Markers, Biological. Proc Natl Acad Sci USA 1989;86(4):1188
short chain trans-2-enoyl-CoA reductase  EC 1.3.1.-   *Fatty Acid Synthetase Complex *NADH, NADPH Oxidoreductases. J Biol Chem 1982; 257(23):14333
mycolate synthetase  EC 6.-   *Fatty Acid Synthetase Complex. Am Rev Respir Dis 110(1):1974
thioesterase II  EC 3.1.2.-   *Fatty Acid Synthetase Complex *Thiolester Hydrolases. J Biol Chem 254(18):8932;1979; J Dairy Sci 1980;63(2):337
beta-ketoacyl thioester reductase  EC 1.1.1.-   *Alcohol Oxidoreductases *Fatty Acid Synthetase Complex. Biomed Mass Spec 5(5):357;1978; J Biol Chem 249(5):1654;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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