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Ferrochelatase

More information in Books or onNLM PubMed
Definition: A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.      Other names Porphyrin-Metal Chelatase; Heme Synthetase; Synthetase, Heme; Protoheme Ferro Lyase; Porphyrin Metal Chelatase; Ferro-Lyase, Protoheme; Chelatase, Zinc; Chelatase, Porphyrin-Metal; Zinc Chelatase; Protoheme Ferro-Lyase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MET8 protein, S cerevisiae  EC 4.99.1.-   *Ferrochelatase *Saccharomyces cerevisiae Proteins. FEBS Lett 1997 Jan 13;401(1):20-4
4-dodecyl-3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethylpyridine  144883-74-9   Dicarbethoxydihydrocollidine/*analogs & derivatives Ferrochelatase/antagonists & inhibitors. Can J Physiol Pharmacol 1992 Aug;70(8):1069-74
N-methylprotoporphyrin dimethyl ester  75675-52-4   *Protoporphyrins Ferrochelatase/antagonists & inhibitors. Biochem J 1982;208(2):479

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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