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Flunarizine

More information in Books or onNLM PubMed
Definition: Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.     
Pharmacological Action Anticonvulsants; Calcium Channel Blockers; Histamine H1 Antagonists; Vasodilator Agents 		Other names R14950; R 14950; Hydrochloride, Flunarizine; Dihydrochloride, Flunarizine; Sibelium; R-14950; Flunarizine Hydrochloride; Flunarizine Dihydrochloride; Flunarizin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-(bis(4-fluorophenyl)methyl)-4-(3-(4'-hydroxyphenyl)-2-propenyl)piperazine  100551-77-7   Flunarizine/*analogs & derivatives. Res Commun Chem Pathol Pharmacol 1992 Oct;78(1):85-95
GBR 13069  77862-93-2   Flunarizine/*analogs & derivatives. Eur J Pharmacol 1984;103(3-4):241

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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