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Fusaric Acid

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Definition: A picolinic acid derivative isolated from various Fusarium species. It has been proposed for a variety of therapeutic applications but is primarily used as a research tool. Its mechanisms of action are poorly understood. It probably inhibits DOPAMINE BETA-HYDROXYLASE, the enzyme that converts dopamine to norepinephrine. It may also have other actions, including the inhibition of cell proliferation and DNA synthesis.  /biosyn permitted if by organism   
Pharmacological Action Dopamine Agents; Enzyme Inhibitors; Nucleic Acid Synthesis Inhibitors 		Other names Fusarate, Calcium; Acid, Fusaric; Acid, 5-Butyl-2-pyridinedicarboxylic; 5 Butyl 2 pyridinedicarboxylic Acid; Calcium Fusarate; 5-Butyl-2-pyridinedicarboxylic Acid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
9,10-dehydrofusaric acid  0   Fusaric Acid/*analogs & derivatives. Phytochem Anal. 2002 Sep-Oct;13(5):277-82
fusarinolic acid  0   Fusaric Acid/*analogs & derivatives. J Org Chem 2001 Jan 26;66(2):605-8
methyl fusarate  0   Fusaric Acid/*analogs & derivatives. J Agric Food Chem 1999 Sep;47(9):3901-4
5-(3'-carboxypropyl)-2-pyridinecarboxylic acid  61361-30-6   Fusaric Acid/*analogs & derivatives. Appl Environ Microbiol 1985;50(2):311
5-(3',4'-dihydroxybutyl)-2-pyridinecarboxylic acid  98985-54-7   Fusaric Acid/*analogs & derivatives. Appl Environ Microbiol 1985;50(2):311
fusaric acid N,N-diethylaminoethylamide  78272-90-9 2-Pyridinecarboxamide, 5-butyl-N-(2-(diethylamino)ethyl)  Fusaric Acid/*analogs & derivatives. Farmakol Toksikol 1982;45(2):63
5-(4'-chlorobutyl)picolinic acid  41135-83-5 5-(4-chlorobutyl)-2-pyridinecarboxylic acid  Fusaric Acid/*analogs & derivatives Dopamine beta-Hydroxylase/antagonists & inhibitors. Arzneim Forsch 25(1):55;1975; Arzneim Forsch 25(2):213;1975; Arzneim Forsch 25(3):383;1975; Chem Pharm Bull (Tokyo) 26(8):2328;1978
bupicomide  22632-06-0 5-n-butylpicolinamide  Fusaric Acid/*analogs & derivatives. Am Heart J 92(3):335;1976; Clin Exp Pharm Physiol 3(3):199;1976; Clin Pharmacol Ther 18(2):145;1975; J Pharmacol 184(3):671;1973; Mayo Clinic Proc 52(7):430;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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