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gamma-Glutamylcyclotransferase

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Definition: An enzyme that catalyzes the synthesis of pyroglutamate from a gamma-glutamyl-amino acid, also releasing the free amino acid. The enzyme acts on derivatives of glutamate, 2-aminobutyrate, alanine and glycine. The enzyme has been proposed to have a role in a gamma-glutamyl cycle for amino acid transport into cells in the intestines. EC 2.3.2.4.  do not confuse with GAMMA-GLUTAMYLTRANSFERASE    Other names gamma Glutamylcyclotransferase; gamma Glutamylamine Cyclotransferase; Cyclotransferase, gamma-Glutamylamine; gamma-Glutamylamine Cyclotransferase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
beta-aminoglutarylalanine  124756-83-8   *Dipeptides gamma-Glutamylcyclotransferase/antagonists & inhibitors. Eur J Biochem 1989;184(1):97
beta-aminoglutaryl-L-alpha-aminobutyrate  64481-03-4 Pentanoic acid, 3-amino-5-((1-carboxypropyl)amino)-5-oxo  *Aminobutyric Acids gamma-Glutamylcyclotransferase/antagonists & inhibitors. J Biol Chem 1980;255(22):10787

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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